2hne

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[[Image:2hne.gif|left|200px]]
 
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{{Structure
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==Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. campestris str. ATCC 33913==
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|PDB= 2hne |SIZE=350|CAPTION= <scene name='initialview01'>2hne</scene>, resolution 2.00&Aring;
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<StructureSection load='2hne' size='340' side='right'caption='[[2hne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[2hne]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HNE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03324 rTSbeta_L-fuconate_dehydratase], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 COG4948]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hne OCA], [https://pdbe.org/2hne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hne RCSB], [https://www.ebi.ac.uk/pdbsum/2hne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hne ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hne TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hne OCA], [http://www.ebi.ac.uk/pdbsum/2hne PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2hne RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/FUCD_XANCP FUCD_XANCP] Plays a role in the catabolism of L-fucose. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. L-fuconate is the preferred substrate with 15-fold lower activity observed for L-galactonate and 8-fold lower activity with D-arabinonate. No activity detected with D-fuconate. Can also catalyze the epimerization of L-talonate and D-ribonate, but at slow rates.<ref>PMID:17144652</ref>
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'''Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. campestris str. ATCC 33913'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2HNE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNE OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/2hne_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hne ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Xanthomonas campestris pv. campestris]]
[[Category: Xanthomonas campestris pv. campestris]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov AA]]
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[[Category: Fedorov, E V.]]
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[[Category: Fedorov EV]]
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[[Category: Gerlt, J A.]]
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[[Category: Gerlt JA]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Yew WS]]
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[[Category: Yew, W S.]]
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[[Category: enolase superfamily]]
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[[Category: l-fuconate dehydratase]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc target t2188]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:29:24 2008''
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Current revision

Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. campestris str. ATCC 33913

PDB ID 2hne

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OCA

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