4xsj

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==Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme==
==Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme==
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<StructureSection load='4xsj' size='340' side='right' caption='[[4xsj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4xsj' size='340' side='right'caption='[[4xsj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xsj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XSJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xsj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XSJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsj OCA], [http://pdbe.org/4xsj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xsj RCSB], [http://www.ebi.ac.uk/pdbsum/4xsj PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsj OCA], [https://pdbe.org/4xsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xsj RCSB], [https://www.ebi.ac.uk/pdbsum/4xsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsj ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D9IEF7_BPT4 D9IEF7_BPT4] [https://www.uniprot.org/uniprot/MCU_HUMAN MCU_HUMAN] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.<ref>PMID:21685886</ref> <ref>PMID:21685888</ref> <ref>PMID:22822213</ref> <ref>PMID:22829870</ref> <ref>PMID:22904319</ref> <ref>PMID:23101630</ref> <ref>PMID:23178883</ref> <ref>PMID:24332854</ref> <ref>PMID:24560927</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4xsj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4xsj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Escherichia virus T4]]
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[[Category: An, J Y]]
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[[Category: Homo sapiens]]
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[[Category: Eom, S H]]
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[[Category: Large Structures]]
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[[Category: Kang, J Y]]
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[[Category: An JY]]
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[[Category: Kang, M]]
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[[Category: Eom SH]]
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[[Category: Kim, D]]
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[[Category: Kang JY]]
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[[Category: Kim, D H]]
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[[Category: Kang M]]
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[[Category: Kim, J H]]
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[[Category: Kim D]]
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[[Category: Kim, T G]]
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[[Category: Kim DH]]
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[[Category: Kim, Y S]]
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[[Category: Kim JH]]
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[[Category: Lee, J G]]
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[[Category: Kim TG]]
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[[Category: Lee, Y]]
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[[Category: Kim Y-S]]
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[[Category: Lim, J J]]
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[[Category: Lee J-G]]
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[[Category: Lim, Y]]
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[[Category: Lee Y]]
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[[Category: Min, C K]]
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[[Category: Lim JJ]]
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[[Category: Park, K R]]
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[[Category: Lim Y]]
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[[Category: Park, Z Y]]
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[[Category: Min CK]]
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[[Category: Shin, K]]
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[[Category: Park KR]]
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[[Category: Song, H K]]
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[[Category: Park ZY]]
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[[Category: Wang, J]]
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[[Category: Shin K]]
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[[Category: Youn, H S]]
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[[Category: Song HK]]
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[[Category: Calcium channel]]
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[[Category: Wang J]]
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[[Category: Membrane protein]]
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[[Category: Youn H-S]]
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[[Category: Mitochondria]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme

PDB ID 4xsj

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