5ac1

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==Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor==
==Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor==
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<StructureSection load='5ac1' size='340' side='right' caption='[[5ac1]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='5ac1' size='340' side='right'caption='[[5ac1]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ac1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AC1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ac1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AC1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K9P:1-[(1S)-1-METHYL-5-OXIDANYL-1,2-DIHYDROBENZO[E]INDOL-3-YL]HEXAN-1-ONE'>K9P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TXE:[[(2R,3S,4R,5R)-5-[(3R)-3-AMINOCARBONYL-3,4-DIHYDRO-2H-PYRIDIN-1-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANIDYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>TXE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5abm|5abm]], [[5ac0|5ac0]], [[5ac2|5ac2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K9P:1-[(1S)-1-METHYL-5-OXIDANYL-1,2-DIHYDROBENZO[E]INDOL-3-YL]HEXAN-1-ONE'>K9P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TXE:[[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>TXE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ac1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ac1 OCA], [https://pdbe.org/5ac1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ac1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ac1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ac1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ac1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ac1 OCA], [http://pdbe.org/5ac1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ac1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ac1 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A1_SHEEP AL1A1_SHEEP]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.
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[https://www.uniprot.org/uniprot/AL1A1_SHEEP AL1A1_SHEEP] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ac1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ac1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Retinal dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Blank, I D]]
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[[Category: Ovis aries]]
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[[Category: Harteis, S]]
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[[Category: Blank ID]]
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[[Category: Koch, M F]]
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[[Category: Harteis S]]
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[[Category: Ochsenfeld, C]]
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[[Category: Koch MF]]
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[[Category: Pestel, G]]
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[[Category: Ochsenfeld C]]
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[[Category: Schneider, S]]
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[[Category: Pestel G]]
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[[Category: Sieber, S A]]
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[[Category: Schneider S]]
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[[Category: Tietze, L F]]
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[[Category: Sieber SA]]
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[[Category: Aldehyde dehydrogenase activity]]
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[[Category: Tietze LF]]
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[[Category: Oxidation-reduction process]]
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[[Category: Oxidoreductase]]
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Current revision

Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor

PDB ID 5ac1

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OCA

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