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5cmn

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==FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain==
==FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain==
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<StructureSection load='5cmn' size='340' side='right' caption='[[5cmn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='5cmn' size='340' side='right'caption='[[5cmn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cmn]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cmn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.605&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cmp|5cmp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmn OCA], [http://pdbe.org/5cmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cmn RCSB], [http://www.ebi.ac.uk/pdbsum/5cmn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmn OCA], [https://pdbe.org/5cmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmn RCSB], [https://www.ebi.ac.uk/pdbsum/5cmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmn ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
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[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] May have a function in cell adhesion and/or receptor signaling. [[http://www.uniprot.org/uniprot/LPHN3_HUMAN LPHN3_HUMAN]] May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex (By similarity).
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[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] May have a function in cell adhesion and/or receptor signaling.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cmn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cmn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Latrophilin|Latrophilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arac, D]]
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[[Category: Homo sapiens]]
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[[Category: Lu, Y]]
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[[Category: Large Structures]]
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[[Category: Salzman, G]]
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[[Category: Arac D]]
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[[Category: Adgrl3]]
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[[Category: Lu Y]]
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[[Category: Cell adhesion-carbohydrate binding complex]]
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[[Category: Salzman G]]
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[[Category: Lrr repeat]]
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Current revision

FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain

PDB ID 5cmn

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