2n7s

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m (Protected "2n7s" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 2n7s is ON HOLD
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==Solution Structure of Leptospiral LigA4 Big Domain==
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<StructureSection load='2n7s' size='340' side='right'caption='[[2n7s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans_serovar_Copenhageni_str._Fiocruz_L1-130 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2n2i 2n2i]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7S FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7s OCA], [https://pdbe.org/2n7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7s RCSB], [https://www.ebi.ac.uk/pdbsum/2n7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72V39_LEPIC Q72V39_LEPIC]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pathogenic Leptospiraspecies express immunoglobulin-like proteins which serve as adhesins to bind to the extracellular matrices of host cells. Leptospiral immunoglobulin-like protein A (LigA), a surface exposed protein containing tandem repeats of bacterial immunoglobulin-like (Big) domains, has been proved to be involved in the interaction of pathogenic Leptospira with mammalian host. In this study, the solution structure of the fourth Big domain of LigA (LigA4 Big domain) from Leptospira interrogans was solved by nuclear magnetic resonance (NMR). The structure of LigA4 Big domain displays a similar bacterial immunoglobulin-like fold compared with other Big domains, implying some common structural aspects of Big domain family. On the other hand, it displays some structural characteristics significantly different from classic Ig-like domain. Furthermore, Stains-all assay and NMR chemical shift perturbation revealed the Ca(2+) binding property of LigA4 Big domain.
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Authors: Mei, S.
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Solution structure of leptospiral LigA4 Big domain.,Mei S, Zhang J, Zhang X, Tu X Biochem Biophys Res Commun. 2015 Nov 13;467(2):288-92. doi:, 10.1016/j.bbrc.2015.09.170. Epub 2015 Oct 9. PMID:26449456<ref>PMID:26449456</ref>
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Description: Solution Structure of Leptospiral LigA4 Big Domain
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Mei, S]]
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<div class="pdbe-citations 2n7s" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]]
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[[Category: Mei S]]

Current revision

Solution Structure of Leptospiral LigA4 Big Domain

PDB ID 2n7s

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