5a9z

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(New page: '''Unreleased structure''' The entry 5a9z is ON HOLD Authors: Kumar, V., Chen, Y., Ahmed, T., Tan, J., Ero, R., Bhushan, S., Gao, Y.-G. Description: Complex of Thermous thermophilus ri...)
Current revision (06:59, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5a9z is ON HOLD
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==Complex of Thermous thermophilus ribosome bound to BipA-GDPCP==
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<SX load='5a9z' size='340' side='right' viewer='molstar' caption='[[5a9z]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5a9z]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A9Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=NMY:NEOMYCIN'>NMY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9z OCA], [https://pdbe.org/5a9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a9z RCSB], [https://www.ebi.ac.uk/pdbsum/5a9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL19_THET8 RL19_THET8] Contacts the 16S rRNA of the 30S subunit (part of bridge B6), connecting the 2 subunits.[HAMAP-Rule:MF_00402]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BPI-inducible protein A (BipA) is a member of the family of ribosome-dependent translational GTPase (trGTPase) factors along with elongation factors G and 4 (EF-G and EF4). Despite being highly conserved in bacteria and playing a critical role in coordinating cellular responses to environmental changes, its structures (isolated and ribosome bound) remain elusive. Here, we present the crystal structures of apo form and GTP analog, GDP, and guanosine-3',5'-bisdiphosphate (ppGpp)-bound BipA. In addition to having a distinctive domain arrangement, the C-terminal domain of BipA has a unique fold. Furthermore, we report the cryo-electron microscopy structure of BipA bound to the ribosome in its active GTP form and elucidate the unique structural attributes of BipA interactions with the ribosome and A-site tRNA in the light of its possible function in regulating translation.
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Authors: Kumar, V., Chen, Y., Ahmed, T., Tan, J., Ero, R., Bhushan, S., Gao, Y.-G.
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Structure of BipA in GTP form bound to the ratcheted ribosome.,Kumar V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Wong AS, Bhushan S, Gao YG Proc Natl Acad Sci U S A. 2015 Aug 17. pii: 201513216. PMID:26283392<ref>PMID:26283392</ref>
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Description: Complex of Thermous thermophilus ribosome bound to BipA-GDPCP
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Kumar, V]]
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<div class="pdbe-citations 5a9z" style="background-color:#fffaf0;"></div>
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[[Category: Gao, Y.-G]]
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[[Category: Chen, Y]]
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==See Also==
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[[Category: Tan, J]]
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*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
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[[Category: Ero, R]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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[[Category: Ahmed, T]]
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== References ==
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[[Category: Bhushan, S]]
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ahmed T]]
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[[Category: Bhushan S]]
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[[Category: Chen Y]]
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[[Category: Ero R]]
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[[Category: Gao Y-G]]
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[[Category: Kumar V]]
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[[Category: Tan J]]

Current revision

Complex of Thermous thermophilus ribosome bound to BipA-GDPCP

5a9z, resolution 4.70Å

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