5ams
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Sqt1== | |
| + | <StructureSection load='5ams' size='340' side='right'caption='[[5ams]], [[Resolution|resolution]] 3.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ams]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ams FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ams OCA], [https://pdbe.org/5ams PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ams RCSB], [https://www.ebi.ac.uk/pdbsum/5ams PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ams ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SQT1_YEAST SQT1_YEAST] May be involved in the late step of 60S ribosomal subunit assembly or modification in the cytoplasm. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ribosome biogenesis in eukaryotes is a complex and highly orchestrated process involving more than 200 accessory factors in addition to ribosomal RNAs and ribosomal proteins. Among the many factors involved, Sqt1p has been reported to specifically bind to uL16 and to act as a chaperone. The crystal structure of full-length Sqt1p from the yeast Saccharomyces cerevisiae has been solved at 3.35 A resolution. A SAD experiment at the Se K edge and an S-SAD experiment on the same selenomethionine-substituted protein crystal allowed unambiguous positioning of the selenomethionine and Cys residues. On the basis of the atomic structure of Sqt1p, the potential residues involved in uL16 interaction were identified and tested. | ||
| - | + | Sqt1p is an eight-bladed WD40 protein.,Frenois F, Legrand P, Fribourg S Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):59-64. doi:, 10.1107/S2053230X15024097. Epub 2016 Jan 1. PMID:26750486<ref>PMID:26750486</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Frenois | + | <div class="pdbe-citations 5ams" style="background-color:#fffaf0;"></div> |
| - | [[Category: Fribourg | + | == References == |
| - | [[Category: Legrand | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Frenois F]] | ||
| + | [[Category: Fribourg S]] | ||
| + | [[Category: Legrand P]] | ||
Current revision
Crystal structure of Sqt1
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