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5dkg

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'''Unreleased structure'''
 
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The entry 5dkg is ON HOLD until Paper Publication
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==Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a t-butyl-substituted, methyl, triaryl-ethylene derivative 4,4'-[2-(4-tert-butylphenyl)prop-1-ene-1,1-diyl]diphenol==
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<StructureSection load='5dkg' size='340' side='right'caption='[[5dkg]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dkg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5C7:4,4-[2-(4-TERT-BUTYLPHENYL)PROP-1-ENE-1,1-DIYL]DIPHENOL'>5C7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkg OCA], [https://pdbe.org/5dkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkg RCSB], [https://www.ebi.ac.uk/pdbsum/5dkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkg ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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Authors: Nwachukwu, J.C., Srinivasan, S., Zheng, Y., Wang, S., Min, J., Dong, C., Liao, Z., Cavett, V., Nowak, J., Houtman, R., Carlson, K.E., Josan, J.S., Elemento, O., Katzenellenbogen, J.A., Zhou, H.B., Nettles, K.W.
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Zheng, Y]]
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__TOC__
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[[Category: Nwachukwu, J.C]]
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</StructureSection>
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[[Category: Liao, Z]]
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[[Category: Homo sapiens]]
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[[Category: Katzenellenbogen, J.A]]
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[[Category: Large Structures]]
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[[Category: Srinivasan, S]]
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[[Category: Carlson KE]]
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[[Category: Min, J]]
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[[Category: Cavett V]]
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[[Category: Carlson, K.E]]
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[[Category: Dong C]]
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[[Category: Houtman, R]]
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[[Category: Elemento O]]
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[[Category: Dong, C]]
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[[Category: Houtman R]]
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[[Category: Cavett, V]]
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[[Category: Josan JS]]
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[[Category: Wang, S]]
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[[Category: Katzenellenbogen JA]]
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[[Category: Nowak, J]]
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[[Category: Liao Z]]
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[[Category: Josan, J.S]]
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[[Category: Min J]]
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[[Category: Nettles, K.W]]
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[[Category: Nettles KW]]
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[[Category: Zhou, H.B]]
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[[Category: Nowak J]]
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[[Category: Elemento, O]]
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[[Category: Nwachukwu JC]]
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[[Category: Srinivasan S]]
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[[Category: Wang S]]
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[[Category: Zheng Y]]
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[[Category: Zhou HB]]

Current revision

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a t-butyl-substituted, methyl, triaryl-ethylene derivative 4,4'-[2-(4-tert-butylphenyl)prop-1-ene-1,1-diyl]diphenol

PDB ID 5dkg

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OCA

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