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5dpt

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'''Unreleased structure'''
 
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The entry 5dpt is ON HOLD
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==Crystal structure of PLEKHM1 LIR-fused human GABARAPL1_2-117==
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<StructureSection load='5dpt' size='340' side='right'caption='[[5dpt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dpt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DPT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dpt OCA], [https://pdbe.org/5dpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dpt RCSB], [https://www.ebi.ac.uk/pdbsum/5dpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dpt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PKHM1_HUMAN PKHM1_HUMAN] Intermediate osteopetrosis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [https://www.uniprot.org/uniprot/PKHM1_HUMAN PKHM1_HUMAN] Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Involved in vesicular transport in the osteoclast (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7 (PubMed:25500191).[UniProtKB:Q5PQS0]<ref>PMID:12820725</ref> <ref>PMID:20943950</ref> <ref>PMID:25498145</ref> <ref>PMID:25500191</ref>
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Authors: Ravichandran, A.C., Suzuki, H., Dobson, R.C.J.
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==See Also==
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*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
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Description: Crystal structure of PLEKHM1 LIR-fused human GABARAPL1_2-117
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Ravichandran, A.C]]
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__TOC__
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[[Category: Suzuki, H]]
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</StructureSection>
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[[Category: Dobson, R.C.J]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dobson RCJ]]
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[[Category: Ravichandran AC]]
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[[Category: Suzuki H]]

Current revision

Crystal structure of PLEKHM1 LIR-fused human GABARAPL1_2-117

PDB ID 5dpt

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