5dtu
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5dtu is ON HOLD until Paper Publication Authors: Tauchert, M.J., Ficner, R. Description: Category: Unreleased Structures [[Category: Tauchert,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the RNA-helicase Prp28 from Chaetomium thermophilum bound to ADP== | |
| + | <StructureSection load='5dtu' size='340' side='right'caption='[[5dtu]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5dtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DTU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.199Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dtu OCA], [https://pdbe.org/5dtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dtu RCSB], [https://www.ebi.ac.uk/pdbsum/5dtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dtu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G0SBQ7_CHATD G0SBQ7_CHATD] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Prp28 (pre-mRNA-splicing ATP-dependent RNA helicase 28) is a spliceosomal DEAD-box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP-independent manner as well as for the formation of the pre-catalytic spliceosome, which in contrast is ATP-dependent. During the latter step, Prp28 is crucial for the integration of the U4/U6.U5 tri-snRNP since it displaces the U1 snRNP and allows the U6 snRNP to base-pair with the 5'-splice site. Here, the crystal structure of Prp28 from the thermophilic fungus Chaetomium thermophilum is reported at 3.2 A resolution and is compared with the available structures of homologues. | ||
| - | + | Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.,Tauchert MJ, Ficner R Acta Crystallogr F Struct Biol Commun. 2016 May 1;72(Pt 5):409-16. doi:, 10.1107/S2053230X16006038. Epub 2016 Apr 22. PMID:27139834<ref>PMID:27139834</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5dtu" style="background-color:#fffaf0;"></div> |
| - | [[Category: Ficner | + | |
| + | ==See Also== | ||
| + | *[[Helicase 3D structures|Helicase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chaetomium thermophilum var. thermophilum DSM 1495]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ficner R]] | ||
| + | [[Category: Tauchert MJ]] | ||
Current revision
Crystal structure of the RNA-helicase Prp28 from Chaetomium thermophilum bound to ADP
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