5djp

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==Crystal structure of human FPPS in complex with biaryl compound 5==
==Crystal structure of human FPPS in complex with biaryl compound 5==
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<StructureSection load='5djp' size='340' side='right' caption='[[5djp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='5djp' size='340' side='right'caption='[[5djp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5djp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5djp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DJP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BJ:4-(NAPHTHALEN-1-YL)-1H-INDOLE-2-CARBOXYLIC+ACID'>5BJ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5diq|5diq]], [[5dgn|5dgn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BJ:4-(NAPHTHALEN-1-YL)-1H-INDOLE-2-CARBOXYLIC+ACID'>5BJ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djp OCA], [http://pdbe.org/5djp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djp RCSB], [http://www.ebi.ac.uk/pdbsum/5djp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5djp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djp OCA], [https://pdbe.org/5djp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5djp RCSB], [https://www.ebi.ac.uk/pdbsum/5djp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5djp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5djp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5djp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bourgier, E]]
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[[Category: Homo sapiens]]
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[[Category: Lehmann, S]]
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[[Category: Large Structures]]
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[[Category: Rondeau, J M]]
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[[Category: Bourgier E]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Lehmann S]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Rondeau JM]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human FPPS in complex with biaryl compound 5

PDB ID 5djp

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