3jbq

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(New page: ==Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6== <StructureSection load='3jbq' size='340' side='right' caption='3jbq, resolution 11....)
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==Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6==
==Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6==
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<StructureSection load='3jbq' size='340' side='right' caption='[[3jbq]], [[Resolution|resolution]] 11.00&Aring;' scene=''>
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<SX load='3jbq' size='340' side='right' viewer='molstar' caption='[[3jbq]], [[Resolution|resolution]] 11.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jbq]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JBQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jbq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JBQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jab|3jab]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jbq OCA], [http://pdbe.org/3jbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jbq RCSB], [http://www.ebi.ac.uk/pdbsum/3jbq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jbq OCA], [https://pdbe.org/3jbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jbq RCSB], [https://www.ebi.ac.uk/pdbsum/3jbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jbq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CNRG_BOVIN CNRG_BOVIN]] Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
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[https://www.uniprot.org/uniprot/PDE5A_BOVIN PDE5A_BOVIN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).[UniProtKB:O76074]<ref>PMID:8530505</ref> [https://www.uniprot.org/uniprot/PDE6C_BOVIN PDE6C_BOVIN] As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.[UniProtKB:P51160]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Agosto, M A]]
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[[Category: Agosto MA]]
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[[Category: Baehr, W]]
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[[Category: Baehr W]]
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[[Category: Baker, M L]]
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[[Category: Baker ML]]
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[[Category: Constantine, R]]
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[[Category: Constantine R]]
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[[Category: He, F]]
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[[Category: He F]]
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[[Category: Schmid, M F]]
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[[Category: Schmid MF]]
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[[Category: Wensel, T G]]
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[[Category: Wensel TG]]
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[[Category: Zhang, Z]]
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[[Category: Zhang Z]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Pde6]]
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[[Category: Phosphodiesterase]]
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[[Category: Photoreceptor]]
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Current revision

Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6

3jbq, resolution 11.00Å

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