4uvg

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==Discovery of pyrimidine isoxazoles InhA in complex with compound 15==
==Discovery of pyrimidine isoxazoles InhA in complex with compound 15==
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<StructureSection load='4uvg' size='340' side='right' caption='[[4uvg]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<StructureSection load='4uvg' size='340' side='right'caption='[[4uvg]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uvg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UVG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UVG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A0C:5-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYLMETHYL]ISOXAZOLE-3-CARBOXAMIDE'>A0C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uvd|4uvd]], [[4uve|4uve]], [[4uvh|4uvh]], [[4uvi|4uvi]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A0C:5-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYLMETHYL]ISOXAZOLE-3-CARBOXAMIDE'>A0C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvg OCA], [https://pdbe.org/4uvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uvg RCSB], [https://www.ebi.ac.uk/pdbsum/4uvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uvg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uvg OCA], [http://pdbe.org/4uvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uvg RCSB], [http://www.ebi.ac.uk/pdbsum/4uvg PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
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==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cowan, S]]
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[[Category: Large Structures]]
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[[Category: Ghorpade, S]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Gingell, H]]
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[[Category: Cowan S]]
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[[Category: Madhavapeddi, P]]
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[[Category: Ghorpade S]]
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[[Category: Read, J A]]
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[[Category: Gingell H]]
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[[Category: Acp enoyl reductase]]
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[[Category: Madhavapeddi P]]
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[[Category: Fblg]]
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[[Category: Read JA]]
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[[Category: Inha]]
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[[Category: Oxidoreductase]]
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[[Category: Pyrimidine isoxazole]]
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Current revision

Discovery of pyrimidine isoxazoles InhA in complex with compound 15

PDB ID 4uvg

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