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5cry

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'''Unreleased structure'''
 
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The entry 5cry is ON HOLD until Paper Publication
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==Structure of iron-saturated C-lobe of bovine lactoferrin at pH 6.8 indicates the softening of iron coordination==
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<StructureSection load='5cry' size='340' side='right'caption='[[5cry]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CRY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cry OCA], [https://pdbe.org/5cry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cry RCSB], [https://www.ebi.ac.uk/pdbsum/5cry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cry ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
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Authors: Singh, A., Rastogi, N., Singh, P.K., Tyagi, T.K., Kaur, P., Sharma, S., Singh, T.P.
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==See Also==
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*[[Lactoferrin|Lactoferrin]]
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Description: Structure of iron-saturated C-lobe of bovine lactoferrin at pH 7.0 indicates the softening of iron coordination
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Singh, P.K]]
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__TOC__
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[[Category: Singh, T.P]]
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</StructureSection>
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[[Category: Rastogi, N]]
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[[Category: Bos taurus]]
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[[Category: Singh, A]]
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[[Category: Large Structures]]
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[[Category: Tyagi, T.K]]
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[[Category: Kaur P]]
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[[Category: Sharma, S]]
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[[Category: Rastogi N]]
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[[Category: Kaur, P]]
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[[Category: Sharma S]]
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[[Category: Singh A]]
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[[Category: Singh PK]]
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[[Category: Singh TP]]
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[[Category: Tyagi TK]]

Current revision

Structure of iron-saturated C-lobe of bovine lactoferrin at pH 6.8 indicates the softening of iron coordination

PDB ID 5cry

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