5duo

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'''Unreleased structure'''
 
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The entry 5duo is ON HOLD until Paper Publication
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==Crystal structure of native translocator protein 18kDa (TSPO) from Rhodobacter sphaeroides (A139T Mutant) in C2 space group==
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<StructureSection load='5duo' size='340' side='right'caption='[[5duo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Li, F., Liu, J., Zheng, Y., Garavito, R.M., Ferguson-Miller, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5duo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DUO FirstGlance]. <br>
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Description: Crystal structure of native translocator protein 18kDa (TSPO) from Rhodobacter sphaeroides (A139T Mutant) in C2 space group
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PP9:PROTOPORPHYRIN+IX'>PP9</scene></td></tr>
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[[Category: Zheng, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5duo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5duo OCA], [https://pdbe.org/5duo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5duo RCSB], [https://www.ebi.ac.uk/pdbsum/5duo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5duo ProSAT]</span></td></tr>
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[[Category: Li, F]]
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</table>
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[[Category: Liu, J]]
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== Function ==
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[[Category: Ferguson-Miller, S]]
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[https://www.uniprot.org/uniprot/TSPO_CERSP TSPO_CERSP] May play a role in the transmembrane transport of tetrapyrroles and similar compounds, and thereby contribute to the regulation of tetrapyrrole biosynthesis (PubMed:10409680). Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX (PubMed:23651039). Binds protoporphyrin IX, hemin, and coproporphyrin III, but does not bind delta-aminolevulinic acid (PubMed:23952237, PubMed:20541505, PubMed:25635101). Can bind bilirubin, curcumin, gossypol, retinoic acid, cholesterol and the benzodiazepine receptor agonist PK-11195 (in vitro) (PubMed:23952237, PubMed:25635101). Plays a role in the response to low oxygen levels and in the regulation of the biosynthesis of photosynthetic pigments (PubMed:7673149, PubMed:10409680, PubMed:10681549).<ref>PMID:10681549</ref> <ref>PMID:20541505</ref> <ref>PMID:23651039</ref> <ref>PMID:23952237</ref> <ref>PMID:25635101</ref> <ref>PMID:7673149</ref> <ref>PMID:10409680</ref>
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[[Category: Garavito, R.M]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cereibacter sphaeroides]]
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[[Category: Large Structures]]
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[[Category: Ferguson-Miller S]]
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[[Category: Garavito RM]]
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[[Category: Li F]]
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[[Category: Liu J]]
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[[Category: Zheng Y]]

Current revision

Crystal structure of native translocator protein 18kDa (TSPO) from Rhodobacter sphaeroides (A139T Mutant) in C2 space group

PDB ID 5duo

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