5e06
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5e06 is ON HOLD Authors: Guo, Y., Wang, W.M., Lou, Z.Y. Description: Structure of Sin Nombre virus nucleoprotein in long-axis crystal form [[Catego...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Sin Nombre virus nucleoprotein in long-axis crystal form== | |
| - | + | <StructureSection load='5e06' size='340' side='right'caption='[[5e06]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sin_Nombre_orthohantavirus Sin Nombre orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E06 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.001Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e06 OCA], [https://pdbe.org/5e06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e06 RCSB], [https://www.ebi.ac.uk/pdbsum/5e06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e06 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Guo | + | == Function == |
| - | [[Category: Lou | + | [https://www.uniprot.org/uniprot/NCAP_SINV NCAP_SINV] Encapsidates the genome protecting it from nucleases (Probable). The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable). The nucleocapsid has a left-handed helical structure (By similarity). As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (PubMed:15650206, PubMed:15254200, PubMed:21378500, PubMed:16971445, PubMed:25062117, PubMed:16775315). Involved in the transcription and replication initiation of vRNA by mediating primer annealing (PubMed:20164193). Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (PubMed:19047634). Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (PubMed:18971945, PubMed:25062117). Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (PubMed:20844026, PubMed:20164193, PubMed:25062117). Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity). Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity). Also displays sequence-unspecific DNA endonuclease activity (PubMed:27261891).[UniProtKB:O36307][UniProtKB:P05133]<ref>PMID:15254200</ref> <ref>PMID:15650206</ref> <ref>PMID:16775315</ref> <ref>PMID:16971445</ref> <ref>PMID:18971945</ref> <ref>PMID:19047634</ref> <ref>PMID:20164193</ref> <ref>PMID:20844026</ref> <ref>PMID:21378500</ref> <ref>PMID:25062117</ref> <ref>PMID:27261891</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sin Nombre orthohantavirus]] | ||
| + | [[Category: Guo Y]] | ||
| + | [[Category: Lou ZY]] | ||
| + | [[Category: Wang WM]] | ||
Current revision
Structure of Sin Nombre virus nucleoprotein in long-axis crystal form
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