5e1o

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m (Protected "5e1o" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5e1o is ON HOLD
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==Crystal structure of NTMT1 in complex with RPKRIA peptide==
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<StructureSection load='5e1o' size='340' side='right'caption='[[5e1o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e1o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E1O FirstGlance]. <br>
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Description: Crystal structure of NTMT1 in complex with RPKRIA peptide
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Min, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1o OCA], [https://pdbe.org/5e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e1o RCSB], [https://www.ebi.ac.uk/pdbsum/5e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1o ProSAT]</span></td></tr>
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[[Category: Bountra, C]]
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</table>
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[[Category: Tempel, W]]
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== Function ==
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[[Category: Arrowsmith, C.H]]
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[https://www.uniprot.org/uniprot/NTM1A_HUMAN NTM1A_HUMAN] Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.<ref>PMID:20481588</ref> <ref>PMID:20668449</ref> <ref>PMID:24090352</ref>
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[[Category: Dong, C]]
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== References ==
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[[Category: Edwards, A.M]]
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<references/>
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[[Category: Structural Genomics Consortium (Sgc)]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Dong C]]
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[[Category: Edwards AM]]
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[[Category: Min J]]
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[[Category: Tempel W]]

Current revision

Crystal structure of NTMT1 in complex with RPKRIA peptide

PDB ID 5e1o

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