5e1t

Structural highlights

Function

TRAF1_HUMAN Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.^{[1] [2] [3] [4] [5] [6]}

See Also

• TNF receptor-associated factor 3D structures

References

1. ↑ Irmler M, Steiner V, Ruegg C, Wajant H, Tschopp J. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS Lett. 2000 Feb 25;468(2-3):129-33. PMID:10692572
2. ↑ Su X, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling. Eur J Immunol. 2006 Jan;36(1):199-206. PMID:16323247 doi:10.1002/eji.200535415
3. ↑ Kato T Jr, Gotoh Y, Hoffmann A, Ono Y. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. Genes Cells. 2008 May;13(5):509-20. doi: 10.1111/j.1365-2443.2008.01182.x. PMID:18429822 doi:10.1111/j.1365-2443.2008.01182.x
4. ↑ Lavorgna A, De Filippi R, Formisano S, Leonardi A. TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway. Mol Immunol. 2009 Oct;46(16):3278-82. doi: 10.1016/j.molimm.2009.07.029. Epub, 2009 Aug 20. PMID:19698991 doi:10.1016/j.molimm.2009.07.029
5. ↑ Wicovsky A, Henkler F, Salzmann S, Scheurich P, Kneitz C, Wajant H. Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene. 2009 Apr 16;28(15):1769-81. doi: 10.1038/onc.2009.29. Epub 2009 Mar 16. PMID:19287455 doi:10.1038/onc.2009.29
6. ↑ Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell. 2010 Apr 9;38(1):101-13. PMID:20385093 doi:10.1016/j.molcel.2010.03.009