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4s1f

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==Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone==
==Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone==
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<StructureSection load='4s1f' size='340' side='right' caption='[[4s1f]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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<StructureSection load='4s1f' size='340' side='right'caption='[[4s1f]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4s1f]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4s1f]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S1F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P2D:PENTANE-2,4-DIONE'>P2D</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.242&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l6w|1l6w]], [[4rxf|4rxf]], [[4rxg|4rxg]], [[4rz4|4rz4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P2D:PENTANE-2,4-DIONE'>P2D</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1f OCA], [http://pdbe.org/4s1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1f RCSB], [http://www.ebi.ac.uk/pdbsum/4s1f PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1f OCA], [https://pdbe.org/4s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s1f RCSB], [https://www.ebi.ac.uk/pdbsum/4s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s1f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
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[https://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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*[[Transaldolase 3D structures|Transaldolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leptihn, S]]
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[[Category: Escherichia coli K-12]]
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[[Category: Samland, A K]]
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[[Category: Large Structures]]
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[[Category: Sandalova, T]]
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[[Category: Leptihn S]]
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[[Category: Schneider, G]]
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[[Category: Samland AK]]
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[[Category: Sprenger, G A]]
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[[Category: Sandalova T]]
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[[Category: Stellmacher, L]]
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[[Category: Schneider G]]
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[[Category: Cytosol]]
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[[Category: Sprenger GA]]
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[[Category: Fructose-6-phosphate aldolase some]]
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[[Category: Stellmacher L]]
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[[Category: Homodecamer]]
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[[Category: Lyase]]
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[[Category: Modification of active lys85 by acetylacetone]]
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[[Category: Tim barrel]]
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Current revision

Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone

PDB ID 4s1f

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