2n7q

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'''Unreleased structure'''
 
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The entry 2n7q is ON HOLD until Paper Publication
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==Structure of the transmembrane domain of human nicastrin in SDS micelles==
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<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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Authors: Li, Y., Liew, L., Li, Q., Kang, C.
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==See Also==
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*[[Gamma secretase|Gamma secretase]]
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Description: Structure of the transmembrane domain of human nicastrin in SDS micelles
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Kang, C]]
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[[Category: Homo sapiens]]
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[[Category: Li, Y]]
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[[Category: Large Structures]]
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[[Category: Liew, L]]
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[[Category: Kang C]]
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[[Category: Li, Q]]
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[[Category: Li Q]]
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[[Category: Li Y]]
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[[Category: Liew L]]

Current revision

Structure of the transmembrane domain of human nicastrin in SDS micelles

PDB ID 2n7q

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