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2n8a

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'''Unreleased structure'''
 
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The entry 2n8a is ON HOLD
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==1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break==
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<StructureSection load='2n8a' size='340' side='right'caption='[[2n8a]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N8A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8a OCA], [https://pdbe.org/2n8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n8a RCSB], [https://www.ebi.ac.uk/pdbsum/2n8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n8a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
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Authors: Neuhaus, D., Eustermann, S., Yang, J., Wu, W.
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Wu, W]]
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__TOC__
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[[Category: Yang, J]]
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</StructureSection>
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[[Category: Neuhaus, D]]
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[[Category: Homo sapiens]]
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[[Category: Eustermann, S]]
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[[Category: Large Structures]]
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[[Category: Eustermann S]]
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[[Category: Neuhaus D]]
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[[Category: Wu W]]
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[[Category: Yang J]]

Current revision

1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break

PDB ID 2n8a

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