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5e5m
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(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5e5m is ON HOLD Authors: Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonnano, J.B., Almo, S.C. Description: Crystal structure of mouse CTLA-4 in com...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse CTLA-4 in complex with nanobody== | |
| + | <StructureSection load='5e5m' size='340' side='right'caption='[[5e5m]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5e5m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.182Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5m OCA], [https://pdbe.org/5e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5m RCSB], [https://www.ebi.ac.uk/pdbsum/5e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CTLA4_MOUSE CTLA4_MOUSE] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[CTLA-4|CTLA-4]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Camelidae]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Almo SC]] |
| - | [[Category: Fedorov | + | [[Category: Bonanno JB]] |
| + | [[Category: Fedorov AA]] | ||
| + | [[Category: Fedorov EV]] | ||
| + | [[Category: Samanta D]] | ||
Current revision
Crystal structure of mouse CTLA-4 in complex with nanobody
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