This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5dit

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (21:43, 28 June 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
 +
==The Fk1 domain of FKBP51 in complex with the new synthetic ligand (1R)-3-(3,4-dimethoxyphenyl)-1-f3-[2-(morpholin-4-yl)ethoxy]phenylgpropyl(2S)-1-[(2S,3R)-2-cyclohexyl-3-hydroxybutanoyl]piperidine-2-carboxylate==
==The Fk1 domain of FKBP51 in complex with the new synthetic ligand (1R)-3-(3,4-dimethoxyphenyl)-1-f3-[2-(morpholin-4-yl)ethoxy]phenylgpropyl(2S)-1-[(2S,3R)-2-cyclohexyl-3-hydroxybutanoyl]piperidine-2-carboxylate==
-
<StructureSection load='5dit' size='340' side='right' caption='[[5dit]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+
<StructureSection load='5dit' size='340' side='right'caption='[[5dit]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5dit]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5dit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DIT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5B8:(1R)-3-(3,4-DIMETHOXYPHENYL)-1-{3-[2-(MORPHOLIN-4-YL)ETHOXY]PHENYL}PROPYL+(2S)-1-[(2S,3R)-2-CYCLOHEXYL-3-HYDROXYBUTANOYL]PIPERIDINE-2-CARBOXYLATE'>5B8</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5B8:(1R)-3-(3,4-DIMETHOXYPHENYL)-1-{3-[2-(MORPHOLIN-4-YL)ETHOXY]PHENYL}PROPYL+(2S)-1-[(2S,3R)-2-CYCLOHEXYL-3-HYDROXYBUTANOYL]PIPERIDINE-2-CARBOXYLATE'>5B8</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dit OCA], [http://pdbe.org/5dit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dit RCSB], [http://www.ebi.ac.uk/pdbsum/5dit PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dit OCA], [https://pdbe.org/5dit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dit RCSB], [https://www.ebi.ac.uk/pdbsum/5dit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dit ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
+
[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 5dit" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dit" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Peptidylprolyl isomerase]]
+
[[Category: Homo sapiens]]
-
[[Category: Bracher, A]]
+
[[Category: Large Structures]]
-
[[Category: Feng, X]]
+
[[Category: Bracher A]]
-
[[Category: Hausch, F]]
+
[[Category: Feng X]]
-
[[Category: Sippel, C]]
+
[[Category: Hausch F]]
-
[[Category: Fk-506 binding domain]]
+
[[Category: Sippel C]]
-
[[Category: Hsp90 cochaperone]]
+
-
[[Category: Immunophiline]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Ligand selectivity]]
+
-
[[Category: Peptidyl-prolyl isomerase]]
+

Current revision

The Fk1 domain of FKBP51 in complex with the new synthetic ligand (1R)-3-(3,4-dimethoxyphenyl)-1-f3-[2-(morpholin-4-yl)ethoxy]phenylgpropyl(2S)-1-[(2S,3R)-2-cyclohexyl-3-hydroxybutanoyl]piperidine-2-carboxylate

PDB ID 5dit

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dit"
Personal tools