4yb9

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==Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation==
==Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation==
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<StructureSection load='4yb9' size='340' side='right' caption='[[4yb9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4yb9' size='340' side='right'caption='[[4yb9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yb9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yb9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YB9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yb9 OCA], [http://pdbe.org/4yb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4yb9 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yb9 OCA], [https://pdbe.org/4yb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4yb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yb9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GTR5_BOVIN GTR5_BOVIN]] Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter (By similarity).
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[https://www.uniprot.org/uniprot/GTR5_BOVIN GTR5_BOVIN] Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity. GLUT5 is also overexpressed in certain tumour cells, and inhibitors are potential drugs for these conditions. Here we describe the crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively. GLUT5 has a major facilitator superfamily fold like other homologous monosaccharide transporters. On the basis of a comparison of the inward-facing structures of GLUT5 and human GLUT1, a ubiquitous glucose transporter, we show that a single point mutation is enough to switch the substrate-binding preference of GLUT5 from fructose to glucose. A comparison of the substrate-free structures of GLUT5 with occluded substrate-bound structures of Escherichia coli XylE suggests that, in addition to global rocker-switch-like re-orientation of the bundles, local asymmetric rearrangements of carboxy-terminal transmembrane bundle helices TM7 and TM10 underlie a 'gated-pore' transport mechanism in such monosaccharide transporters.
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Structure and mechanism of the mammalian fructose transporter GLUT5.,Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D Nature. 2015 Sep 30. doi: 10.1038/nature14909. PMID:26416735<ref>PMID:26416735</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4yb9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drew, D]]
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[[Category: Bos taurus]]
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[[Category: Iwata, S]]
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[[Category: Large Structures]]
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[[Category: Kang, H J]]
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[[Category: Drew D]]
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[[Category: Verdon, G]]
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[[Category: Iwata S]]
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[[Category: Bovine mf]]
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[[Category: Kang HJ]]
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[[Category: Fructose]]
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[[Category: Verdon G]]
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[[Category: Glut5 transporter]]
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[[Category: Open inward-facing conformation]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation

PDB ID 4yb9

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