4r16

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==Structure of UDP-D-MAnNAc dehdrogeanse from Pyrococcus horikoshii==
==Structure of UDP-D-MAnNAc dehdrogeanse from Pyrococcus horikoshii==
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<StructureSection load='4r16' size='340' side='right' caption='[[4r16]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4r16' size='340' side='right'caption='[[4r16]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r16]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R16 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r16]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R16 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAJ:(2S,3S,4R,5S,6R)-5-ACETAMIDO-6-[[[(2R,3S,4R,5R)-5-[2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>SAJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAJ:(2S,3S,4R,5S,6R)-5-(acetylamino)-6-{[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-carboxylic+acid+(non-preferred+name)'>SAJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r16 OCA], [http://pdbe.org/4r16 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r16 RCSB], [http://www.ebi.ac.uk/pdbsum/4r16 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r16 OCA], [https://pdbe.org/4r16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r16 RCSB], [https://www.ebi.ac.uk/pdbsum/4r16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r16 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WECC_PYRHO WECC_PYRHO] Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).[UniProtKB:Q6LZC3]<ref>PMID:25305481</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kunishima, N]]
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[[Category: Large Structures]]
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[[Category: Lokanath, N K]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Pampa, K J]]
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[[Category: Kunishima N]]
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[[Category: Rai, R V]]
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[[Category: Lokanath NK]]
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[[Category: Oxidoreductase]]
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[[Category: Pampa KJ]]
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[[Category: Rossmann fold]]
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[[Category: Rai RV]]

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Structure of UDP-D-MAnNAc dehdrogeanse from Pyrococcus horikoshii

PDB ID 4r16

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