4ucs

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==Fragment bound to H.influenza NAD dependent DNA ligase==
==Fragment bound to H.influenza NAD dependent DNA ligase==
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<StructureSection load='4ucs' size='340' side='right' caption='[[4ucs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4ucs' size='340' side='right'caption='[[4ucs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ucs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ucs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UCS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9MJ:5-AMINO-3-(FURAN-2-YL)-1H-1,2,4-TRIAZOLE-1-CARBOXAMIDE'>9MJ</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uco|4uco]], [[4ucr|4ucr]], [[4uct|4uct]], [[4ucu|4ucu]], [[4ucv|4ucv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9MJ:5-AMINO-3-(FURAN-2-YL)-1H-1,2,4-TRIAZOLE-1-CARBOXAMIDE'>9MJ</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ucs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucs OCA], [https://pdbe.org/4ucs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ucs RCSB], [https://www.ebi.ac.uk/pdbsum/4ucs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ucs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ucs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucs OCA], [http://pdbe.org/4ucs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ucs RCSB], [http://www.ebi.ac.uk/pdbsum/4ucs PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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[https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boriack-Sjodin, P A]]
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[[Category: Haemophilus influenzae]]
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[[Category: Brassington, C]]
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[[Category: Large Structures]]
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[[Category: Carcanague, D]]
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[[Category: Boriack-Sjodin PA]]
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[[Category: Embrey, K]]
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[[Category: Brassington C]]
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[[Category: Eyermann, C J]]
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[[Category: Carcanague D]]
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[[Category: Giacobbe, R A]]
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[[Category: Embrey K]]
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[[Category: Gingipali, L]]
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[[Category: Eyermann CJ]]
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[[Category: Gowravaram, M]]
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[[Category: Giacobbe RA]]
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[[Category: Hale, M]]
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[[Category: Gingipali L]]
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[[Category: Harang, J]]
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[[Category: Gowravaram M]]
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[[Category: Howard, T]]
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[[Category: Hale M]]
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[[Category: Ioannidis, G]]
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[[Category: Harang J]]
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[[Category: Jahic, H]]
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[[Category: Howard T]]
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[[Category: Kutschke, A]]
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[[Category: Ioannidis G]]
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[[Category: Laganas, V A]]
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[[Category: Jahic H]]
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[[Category: Loch, J]]
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[[Category: Kutschke A]]
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[[Category: Miller, M D]]
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[[Category: Laganas VA]]
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[[Category: Murphy-Benenato, K E]]
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[[Category: Loch J]]
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[[Category: Oguto, H]]
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[[Category: Miller MD]]
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[[Category: Otterbein, L]]
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[[Category: Murphy-Benenato KE]]
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[[Category: Patel, S J]]
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[[Category: Oguto H]]
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[[Category: Shapiro, A B]]
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[[Category: Otterbein L]]
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[[Category: Ligase]]
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[[Category: Patel SJ]]
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[[Category: Shapiro AB]]

Current revision

Fragment bound to H.influenza NAD dependent DNA ligase

PDB ID 4ucs

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