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NAD kinase

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<StructureSection load='1z0u' size='340' side='right' caption='NAD kinase complex with NADP and sulfate (PDB code [[1z0u]]' scene=''>
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<StructureSection load='' size='350' side='right' caption='NAD kinase complex with NADP and sulfate (PDB code [[1z0u]])' scene='71/715900/Cv/1'>
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'''NAD kinase''' (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism.
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== Function ==
== Function ==
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'''NAD kinase''' or '''ATP-dependent NAD kinase''' (NADK) catalyzes the conversion of ATP and [[NAD]] to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism<ref>PMID:23212377</ref>. See [[NAD]] and [[NAD(P)H]].
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== Disease ==
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='71/715900/Cv/5'>NADP is bound to NADK</scene> in a cleft between the N and C-terminal domains in the dimer interface<ref>PMID:16242716</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
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*NAD kinase
*NAD kinase
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**[[1u0r]], [[1u0t]] – MtNADK – Mycobacterium tuberculosis<br />
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**[[3pfn]], [[7r4j]] – hNADK catalytic domain 61-442 – human<br />
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**[[1u0r]], [[1u0t]] – MtNADK – ''Mycobacterium tuberculosis''<br />
**[[1y3h]] – MtNADK (mutant)<br />
**[[1y3h]] – MtNADK (mutant)<br />
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**[[1yt5]] – NADK – Thermotoga maritima<br />
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**[[1yt5]] – NADK – ''Thermotoga maritima''<br />
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**[[2i1w]] – LmNADK – Listeria monocytogenes<br />
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**[[2i1w]] – LmNADK – ''Listeria monocytogenes''<br />
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**[[4hao]] – NADK – Yersinia pestis<br />
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**[[5ejf]], [[5ejg]], [[5ejh]] – LmNADK (mutant) <br />
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**[[4hao]] – NADK – ''Yersinia pestis''<br />
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**[[3pfn]] – NADK – human<br />
*NAD kinase complex
*NAD kinase complex
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**[[7r4k]], [[7r4l]], [[7r4m]] – hNADK 2 catalytic domain + NADP<br />
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**[[7n29]] – hNADK 2 catalytic domain + NAD<br />
**[[1y3i]] – MtNADK + NAD<br />
**[[1y3i]] – MtNADK + NAD<br />
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**[[1z0s]] – AfNADK + ATP + PPi – Archaeoglobus fulgidus<br />
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**[[1z0s]] – AfNADK + ATP + PPi – ''Archaeoglobus fulgidus''<br />
**[[1z0u]] – AfNADK + NADP<br />
**[[1z0u]] – AfNADK + NADP<br />
**[[1z0z]] – AfNADK + NAD<br />
**[[1z0z]] – AfNADK + NAD<br />
**[[2i29]] – LmNADK + NAD<br />
**[[2i29]] – LmNADK + NAD<br />
**[[2i2a]] – LmNADK + NADP<br />
**[[2i2a]] – LmNADK + NADP<br />
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**[[2i2b]], [[2i2c]], [[2i2d]], [[4dy6]], [[3v7u]], [[3v7w]], [[3v7y]], [[3v80]], [[3v8m]], [[3v7n]], [[3v7p]] – LmNADK + adenosine derivative<br />
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**[[2i2b]], [[2i2c]], [[2i2d]], [[4dy6]], [[3v7u]], [[3v7w]], [[3v7y]], [[3v80]], [[3v8m]], [[3v8n]], [[3v8p]], [[5dhp]], [[5dhq]], [[5dhr]], [[5dhs]], [[5dht]], [[5dhu]], [[6z61]], [[6z64]], [[6z65]], [[7zz7]], [[7zz9]], [[7zza]], [[7zzb]], [[7zzc]], [[7zzd]], [[7zze]], [[7zzg]], [[7zzh]], [[7zzj]], [[8a9v]], [[8b47]] – LmNADK + adenosine derivative inhibitor<br />
**[[2q5f]], [[3v8q]], [[3v8r]] – LmNADK (mutant) + adenosine derivative<br />
**[[2q5f]], [[3v8q]], [[3v8r]] – LmNADK (mutant) + adenosine derivative<br />
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**[[6rbo]], [[6rbp]], [[6rbq]], [[6rbr]], [[6rbs]], [[6rbt]], [[6rbu]], [[6rbv]], [[6rbw]], [[6rbx]], [[6rby]], [[6rbz]], [[6rc0]], [[6rc1]], [[6rc2]], [[6rc3]], [[6rc4]], [[6rc5]], [[6rc6]], [[6rr2]] – LmNADK + adenine derivative<br />
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**[[6rg6]], [[6rg7]], [[6rg8]], [[6rg8]], [[6rg9]], [[6rga]], [[6rgb]], [[6rgc]], [[6rgd]], [[6rge]], [[6rgf]] – LmNADK + inhibitor<br />
**[[2i2f]] – LmNADK (mutant) + NAD + Pi<br />
**[[2i2f]] – LmNADK (mutant) + NAD + Pi<br />
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**[[5eji]] – LmNADK (mutant) + NADP + PPi<br />
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**[[7mh7]], [[7qvs]] – NADK + NADP – ''Pseudomonas aeruginosa''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

NAD kinase complex with NADP and sulfate (PDB code 1z0u)

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3D structures of NAD kinase

Updated on 11-July-2023

References

  1. ↑ Ohashi K, Kawai S, Murata K. Identification and characterization of a human mitochondrial NAD kinase. Nat Commun. 2012;3:1248. doi: 10.1038/ncomms2262. PMID:23212377 doi:http://dx.doi.org/10.1038/ncomms2262
  2. ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 doi:10.1016/j.jmb.2005.09.026

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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