5e7d
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5e7d is ON HOLD Authors: Filippakopoulos, P., Picaud, S., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Owen, D., Knapp, S., Structural...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand== | |
| - | + | <StructureSection load='5e7d' size='340' side='right'caption='[[5e7d]], [[Resolution|resolution]] 1.87Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5e7d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E7D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5KL:(2E)-3-(DIMETHYLAMINO)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE'>5KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e7d OCA], [https://pdbe.org/5e7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e7d RCSB], [https://www.ebi.ac.uk/pdbsum/5e7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e7d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Bountra | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Filippakopoulos P]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Owen D]] | ||
| + | [[Category: Picaud S]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
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