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2ri1

From Proteopedia

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(New page: 200px {{Structure |PDB= 2ri1 |SIZE=350|CAPTION= <scene name='initialview01'>2ri1</scene>, resolution 2.030&Aring; |SITE= <scene name='pdbsite=AC1:Glp+Binding+Site...)
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[[Image:2ri1.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans==
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|PDB= 2ri1 |SIZE=350|CAPTION= <scene name='initialview01'>2ri1</scene>, resolution 2.030&Aring;
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<StructureSection load='2ri1' size='340' side='right'caption='[[2ri1]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Glp+Binding+Site+For+Residue+A+234'>AC1</scene>, <scene name='pdbsite=AC2:Glp+Binding+Site+For+Residue+B+234'>AC2</scene>, <scene name='pdbsite=AC3:Btb+Binding+Site+For+Residue+B+235'>AC3</scene> and <scene name='pdbsite=AC4:Btb+Binding+Site+For+Residue+A+235'>AC4</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene>
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<table><tr><td colspan='2'>[[2ri1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RI1 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-6-phosphate_deaminase Glucosamine-6-phosphate deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.99.6 3.5.99.6] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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|GENE= SMU.636 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1309 Streptococcus mutans])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01399 GlcN6P_deaminase]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ri1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ri1 OCA], [https://pdbe.org/2ri1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ri1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ri1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ri1 ProSAT]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ri1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ri1 OCA], [http://www.ebi.ac.uk/pdbsum/2ri1 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2ri1 RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/NAGB_STRMU NAGB_STRMU] Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2ri1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ri1 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans'''
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==See Also==
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*[[Deaminase 3D structures|Deaminase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2RI1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RI1 OCA].
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[[Category: Large Structures]]
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[[Category: Glucosamine-6-phosphate deaminase]]
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[[Category: Single protein]]
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[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
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[[Category: Li, D.]]
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[[Category: Li D]]
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[[Category: Liu, C.]]
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[[Category: Liu C]]
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[[Category: Su, X D.]]
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[[Category: Su XD]]
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[[Category: carbohydrate metabolism]]
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[[Category: glucosamine 6-phosphate (glcn6p)]]
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[[Category: glucosamine 6-phosphate deaminase]]
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[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 09:53:27 2008''
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Current revision

Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans

PDB ID 2ri1

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