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4z8g

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==Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2 (TL1 ABS2)==
==Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2 (TL1 ABS2)==
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<StructureSection load='4z8g' size='340' side='right' caption='[[4z8g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4z8g' size='340' side='right'caption='[[4z8g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z8g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z8G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z8g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z8G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z94|4z94]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8g OCA], [http://pdbe.org/4z8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z8g RCSB], [http://www.ebi.ac.uk/pdbsum/4z8g PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8g OCA], [https://pdbe.org/4z8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z8g RCSB], [https://www.ebi.ac.uk/pdbsum/4z8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z8g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TMOD1_HUMAN TMOD1_HUMAN]] Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.<ref>PMID:8002995</ref>
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[https://www.uniprot.org/uniprot/LMOD1_HUMAN LMOD1_HUMAN] [https://www.uniprot.org/uniprot/TMOD1_HUMAN TMOD1_HUMAN] Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.<ref>PMID:8002995</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boczkowska, M]]
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[[Category: Homo sapiens]]
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[[Category: Dominguez, R]]
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[[Category: Large Structures]]
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[[Category: Rebowski, G]]
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[[Category: Boczkowska M]]
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[[Category: Actin nucleator]]
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[[Category: Dominguez R]]
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[[Category: Leucine rich repeat domain]]
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[[Category: Rebowski G]]
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[[Category: Protein binding]]
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Current revision

Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2 (TL1 ABS2)

PDB ID 4z8g

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