Adenosine kinase

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<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (stick model), Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene=''>
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<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene='57/573962/Cv/1'>
== Function ==
== Function ==
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'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.
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'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.<ref>PMID:18560757</ref>
== Disease ==
== Disease ==
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AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.
AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.
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== Structural highlights ==
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</StructureSection>
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AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
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*<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres.
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*<scene name='57/573962/Cv/7'>Cl coordination site</scene>.
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*<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>.
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*<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>.
==3D structures of adenosine kinase==
==3D structures of adenosine kinase==
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[[Adenosine kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Adenosine kinase
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**[[1lio]] – TgAdK – ''Toxoplasma gondii''<br />
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**[[2pkf]] – MtAdK – ''Mycobacterium tuberculosis''<br />
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**[[4n08]] – TbAdK – ''Trypanosoma brucei''<br />
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*Adenosine kinase binary complex
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**[[1bx4]] – hAdK + adenosine - human<br />
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**[[2i6a]], [[2i6b]] – hAdK + prodrug <br />
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**[[4o1l]] – hAdK + inhibitor <br />
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**[[1dgm]], [[1lik]] – TgAdK + adenosine <br />
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**[[2a9y]] – TgAdK (mutant) + dimethyladenosine <br />
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**[[2abs]] – TgAdK (mutant) + AMP-PCP<br />
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**[[2aa0]] – TgAdK (mutant) + methylthiopurine <br />
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**[[2pkk]], [[4ube]] – MtAdK + fluoroadenosine <br />
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**[[2pkn]] – MtAdK + AMP-PCP<br />
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**[[2pkm]] – MtAdK + adenosine <br />
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**[[4o1g]] – MtAdK + γ-thio-ATP <br />
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**[[4pvv]] – MtAdK + inhibitor <br />
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**[[3loo]] – AdK + adenosine tetraphosphate – ''Anopheles gambiae''<br />
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**[[2xtb]] – TbAdK + morpholine <br />
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*Adenosine kinase ternary complex
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**[[1lii]] – TgAdK + adenosine + AMP-PCP<br />
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== References ==
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**[[2a9z]] – TgAdK (mutant) + dimethyladenosine + AMP-PCP<br />
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<references/>
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**[[1lij]] – TgAdK + prodrug + AMP-PCP<br />
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**[[2ab8]] – TgAdK (mutant) + methylthiopurine + AMP-PCP<br />
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**[[3ubo]] – AdK + adenosine + ADP – ''Sinorhizobium meliloti''<br />
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**[[4dc3]] – AdK + adenosine + fluoroadenosine – ''Schistosoma masoni''<br />
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**[[4n09]] – TbAdK + adenosine + ADP <br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

References

  1. ↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
  2. ↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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