Aldose Reductase
From Proteopedia
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| - | <StructureSection load='1ads' size=' | + | <StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> |
== Function == | == Function == | ||
| - | [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. | + | [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref> |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | AldR structure is of a β/α-barrel. The active site is located in the barrel core. | + | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> |
| + | *<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres. | ||
| + | *<scene name='43/436098/Cv/9'>Active site tunnel</scene>. | ||
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| + | == 3D Structures of aldose reductase == | ||
| + | [[Aldose reductase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Aldose Reductase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Aldose Reductase | ||
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| - | **[[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br /> | ||
| - | **[[2alr]] – hAldR <br /> | ||
| - | **[[1xgd]] – hAldR (mutant)<br /> | ||
| - | **[[3q67]] – hAldR (mutant)+NADP<br /> | ||
| - | **[[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br /> | ||
| - | **[[3afn]] - SsAldR A1-R+NADP<br /> | ||
| - | **[[1dla]], [[1cwn]] – pAldR - pig<br /> | ||
| - | **[[1ah4]], [[3cv7]] - pAldR+NADP<br /> | ||
| - | **[[1hqt]] – pAldR (mutant) + NADP<br /> | ||
| - | **[[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br /> | ||
| - | **[[2bgq]] – bAldR - barley<br /> | ||
| - | **[[2bgs]] - bAldR+NADP<br /> | ||
| - | **[[4gca]] – AldR – mouse<br /> | ||
| - | **[[4hbk]] – AldR – ''Schistosoma japonicum''<br /> | ||
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| - | *Aldose Reductase+inhibitors | ||
| - | + | == References == | |
| - | + | <references/> | |
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
- ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098
