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Ankyrin

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<Structure load='1n11' size='500' frame='true' align='right' caption='Human ankyrin-1 D34 region complex with Cl- (green) and Br- (dark red) ions [[1n11]]' scene='Insert optional scene name here' />
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<StructureSection load='1n11' size='350' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>
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== Function ==
== Function ==
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*[[Group:MUZIC:DARP]].
*[[Group:MUZIC:DARP]].
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== Structural highlights ==
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In mammals ANK is encoded by 3 genes: ANK1, ANK2 and ANK3.<br />
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*'''ANK1''' or '''ankyrin-R''' is found in erythrocytes, brain and muscle.<br />
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*'''ANK2''' or '''ankyrin-B''' is found in brain and muscle.<br />
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*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br />
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Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of 2 α-helices connected by a loop.
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'''Gankyrin''' or '''26S proteasome non-ATPase regulatory subunit 10''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats.
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== 3D Structures of Ankyrin ==
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== Disease ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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Mutations in erythrocyte ANK1 are associated with spherocytosis. Mutations in ANK2 are associated with cardiac arrhythmia syndrome. Mutations in ANK3 are associated with bipolar disorder.
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Ankyrin
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== Relevance ==
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GANK is overexpressed in hepatocellular carcinoma.
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== Structural highlights ==
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**[[1n11]] – hANK-1 D34 region – human<br />
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Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>
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**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />
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**[[3f59]] – hANK-1 spectrin-binding domain<br />
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**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />
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**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
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**[[4o6x]] - hANK-3 death domain<br />
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**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
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**[[4rlv]] - hANK-1 + hANK-2<br />
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**[[3so8]] – hANK-A residues 149-310<br />
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**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
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**[[1svx]] – dANK + maltose-binding protein<br />
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**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
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**[[2aja]] – ANK – Legionella pneumophila<br />
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**[[3hra]] – ANK – Enterococus faecalis<br />
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**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
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*Gankyrin
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== 3D Structures of ankyrin ==
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[[Ankyrin 3D structures]]
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</StructureSection>
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**[[1uoh]], [[1qym]] – hGANK<br />
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== References ==
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**[[1tr4]] – hGANK – NMR<br />
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<references/>
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**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions 1n11

Drag the structure with the mouse to rotate

References

  1. ↑ Michaely P, Tomchick DR, Machius M, Anderson RG. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646
  2. ↑ Mosavi LK, Minor DL Jr, Peng ZY. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16029-34. Epub 2002 Dec 2. PMID:12461176 doi:http://dx.doi.org/10.1073/pnas.252537899

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Michal Harel, Alexander Berchansky, Narendra Kumar Verma

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