Aldose Reductase

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<StructureSection load='1ads' size='340' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'>
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<StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'>
== Function ==
== Function ==
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref>
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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AldR structure is of a β/α-barrel. The active site is located in the barrel core.
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AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref>
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*<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres.
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*<scene name='43/436098/Cv/9'>Active site tunnel</scene>.
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== 3D Structures of aldose reductase ==
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[[Aldose reductase 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of Aldose Reductase ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Aldose Reductase
 
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**[[1abn]], [[1ads]], [[3q65]] - hAldR +NADP – human<br />
 
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**[[2alr]] – hAldR <br />
 
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**[[1xgd]] – hAldR (mutant)<br />
 
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**[[3q67]] – hAldR (mutant)+NADP<br />
 
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**[[3afm]] – SsAldR A1-R – ''Sphingomonas sp.''<br />
 
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**[[3afn]] - SsAldR A1-R+NADP<br />
 
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**[[1dla]], [[1cwn]] – pAldR - pig<br />
 
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**[[1ah4]], [[3cv7]] - pAldR+NADP<br />
 
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**[[1hqt]] – pAldR (mutant) + NADP<br />
 
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**[[3krb]] – AldR+NADP – ''Ghiardia lamblia''<br />
 
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**[[2bgq]] – bAldR - barley<br />
 
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**[[2bgs]] - bAldR+NADP<br />
 
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**[[4gca]] – AldR – mouse<br />
 
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**[[4hbk]] – AldR – ''Schistosoma japonicum''<br />
 
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*Aldose Reductase+inhibitors
 
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**[[3ghr]], [[3ghs]], [[3ght]], [[3ghu]], [[2r24]], [[2pzn]], [[3g5e]], [[2qxw]], [[2iki]], [[2i16]], [[2i17]], [[1t40]], [[1t41]], [[1us0]], [[1el3]], [[3t42]] - hAldR +NADP+IDD inhibitors<br />
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== References ==
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**[[3onb]], [[3onc]] – hAldR (mutant) +NADP+IDD inhibitor<br />
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<references/>
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**[[3u2c]] - hAldR +NADP+ NSAID inhibitor<br />
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**[[3bcj]], [[1x97]], [[1x98]], [[1pwm]], [[1ef3]], [[2pd5]], [[2dux]], [[2duz]], [[2dv0]], [[2fz8]], [[2fz9]], [[2hv5]], [[2hvn]], [[2hvo]], [[1mar]], [[2fzb]], [[2fzd]], [[1z3n]], [[1pwl]], [[1iei]], [[4jir]] - hAldR+NADP+inhibitor for diabetic treatment<br />
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**[[1z89]], [[1z8a]] - hAldR+NADP+sulfonyl-pyridazinone<br />
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**[[2pdg]], [[2pdh]] - hAldR+NADP+uracil inhibitor<br />
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**[[2j8t]], [[1x96]], [[2acs]], [[2acu]] - hAldR+NADP+citrate<br />
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**[[2acq]] - hAldR +NADP+glucose phosphate<br />
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**[[2acr]] - hAldR +NADP+cacodylate<br />
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**[[2ikg]], [[2ikh]], [[2ikj]], [[3v35]] - hAldR+NADP+nitro-substituted inhibitor<br />
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**[[3v36]] - hAldR+NADP+ glyceraldehyde + azine<br />
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**[[2nvc]], [[2nvd]] - hAldR+NADP+isothiazole inhibitor<br />
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**[[3p2v]] - hAldR+NADP+ benzothiazepine inhibitor<br />
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**[[2pev]], [[2pf8]], [[2pfh]] - hAldR+NADP+IDD inhibitor+ fidarestat<br />
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**[[2ipw]], [[2iq0]], [[2iqd]], [[2isf]], [[2ine]], [[2inz]], [[2is7]] - hAldR+NADP+ acid<br />
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**[[2f2k]] - hAldR+NADP+DEG<br />
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**[[2pdn]], [[2pdq]] – hAldR (mutant)+NADP+uracil inhibitor<br />
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**[[2pdb]], [[2pdf]], [[2pdi]], [[2pdm]], [[2pdx]], [[3len]], [[3m0i]], [[3mb9]], [[2pd9]], [[2pdw]], [[2pdy]], [[2agt]], [[2pdl]] – hAldR (mutant)+NADP+inhibitor for diabetic treatment<br />
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**[[2pdk]] - hAldR (mutant)+NADP+sorbinil<br />
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**[[1az1]] – hAldR (mutant)+NADP+alrestatin<br />
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**[[1az2]] - hAldR (mutant)+NADP+citrate<br />
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**[[3lbo]], [[3ld5]], [[3lql]], [[3lz5]], [[2pdc]], [[3lep]], [[3lqg]], [[3lz3]], [[3m4h]], [[2pdj]], [[2pdp]], [[2pdu]], [[3m64]], [[3mc5]] - hAldR (mutant)+IDD inhibitors<br />
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**[[3dn5]] – hAldR+NADP+biaryl inhibitor<br />
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**[[3v9q]] - hAldR+NADP+ phenol derivative<br />
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**[[3rx2]], [[3rx3]], [[3rx4]], [[3s3g]] - hAldR+NADP+ sulindac inhibitor<br />
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**[[4igs]] - hAldR+NADP+ polyfluorinated inhibitor<br />
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**[[4lau]], [[4laz]], [[4lb3]], [[4lb4]], [[4lbr]], [[4lbs]] - hAldR+NADP+ carbamoyl inhibitor<br />
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**[[3fx4]] – pAldR+NADP+thiazolidine derivative <br />
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**[[3h4g]] – pAldR+NADP+fidarestat<br />
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**[[1ah3]], [[1ae4]] - pAldR+NADP+tolrestat<br />
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**[[1ah0]] - pAldR+NADP+sorbinil<br />
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**[[1eko]] - pAldR+NADP+IDD inhibitor<br />
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**[[2vdg]] – bAldR+NADP+butanol <br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human aldose reductase complex with cofactor NADP (PDB code 1ads)

Drag the structure with the mouse to rotate

References

  1. ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
  2. ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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