Arylamine N-acetyltransferase

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{{STRUCTURE_2pfr| PDB=2pfr | SIZE=400| SCENE= |right|CAPTION=Arylamine N-acetyltransferase complex with hydrazinophthalazine and formate [[3ltw]] }}
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<StructureSection load='2pqt' size='350' side='right' caption='Human arylamine N-acetyltransferase 1 with active site Cys intermediate complex with Cl- (green) (PDB code [[2pqt]])' scene='48/486362/Cv/1'>
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<StructureSection load='2pfr' size='340' side='right' caption='Human arylamine N-acetyltransferase 2 complex CoA (PDB code [[2pfr]])' scene=''>
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== Function ==
== Function ==
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'''Arylamine N-acetyltransferase''' (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine.
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'''Arylamine N-acetyltransferase''' (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. Human NAT have 2 polymorphs with different substrate specificities. '''NAT1''' acetylates p-aminisalycilates while '''NAT2''' acetylates hydralazine.
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== Disease ==
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Human NAT1 is overexpressed in some kinds of breast cancer.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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NAT acetylates using a <scene name='48/486362/Cv/4'>catalytic Cys-His-Asp triad</scene> (magenta). <ref>PMID:17656365</ref> TYX is colored in salmon.
==3D structures of arylamine N-acetyltransferase==
==3D structures of arylamine N-acetyltransferase==
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[[Arylamine N-acetyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Arylamine N-acetyltransferase
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**[[1gx3]] – MsNAT – ''Mycobacterium smegmatis''<br />
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**[[1w5r]] – MsNAT (mutant)<br />
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**[[2bsz]] – RlNAT1 – ''Rhizobium loti''<br />
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**[[4nv8]] – RlNAT (mutant)<br />
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**[[2ija]] – hNAT1 (mutant) – human<br />
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**[[1w4t]] – NAT – ''Pseudomonas aeruginosa''<br />
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**[[3d9w]] – NAT – ''Nocardia farcinica''<br />
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**[[3lnb]] – NAT (mutant) – ''Bacillus anthracis''<br />
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**[[2vfb]], [[4c5p]] - MmNAT – ''Mycobacterium marinum''<br />
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**[[4bgf]] - NAT – ''Mycobacterium tuberculosis''<br />
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*Arylamine N-acetyltransferase binary complex
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**[[2pqt]] - hNAT1 + Cys intermediate<br />
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**[[2pfr]] – hNAT2 + CoA<br />
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**[[2vfc]] – MmNAT + CoA<br />
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**[[3ltw]] – MmNAT + hydralazine<br />
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**[[1w6f]] – MsNAT + anti-tubercular drug<br />
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**[[4b55]] – MmNAT + piperidinol derivative<br />
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**[[4nv7]] – RlNAT + CoA<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human arylamine N-acetyltransferase 1 with active site Cys intermediate complex with Cl- (green) (PDB code 2pqt)

Drag the structure with the mouse to rotate

References

  1. ↑ Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN. Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J Biol Chem. 2007 Oct 12;282(41):30189-97. Epub 2007 Jul 26. PMID:17656365 doi:10.1074/jbc.M704138200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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