Ascorbate peroxidase

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{{STRUCTURE_1oaf| PDB=1oaf | SIZE=400| SCENE= |right| CAPTION=Soybean heme-containing ascorbate peroxidase complex with ascorbate and Na+ ion (purple), [[1oaf]] }}
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<StructureSection load='1oaf' size='350' side='right' scene='48/486478/Cv/1' caption='Soybean heme-containing ascorbate peroxidase complex with ascorbate and Na+ ion (purple), [[1oaf]]'>
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== Function ==
== Function ==
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APX is part of plants antioxidant defense. APX converts H2O2 to water using ascorbate as an electron donor. APX is used in electron microscopy as a genetic tag which can be stained independently of light activation.
APX is part of plants antioxidant defense. APX converts H2O2 to water using ascorbate as an electron donor. APX is used in electron microscopy as a genetic tag which can be stained independently of light activation.
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==3D structures of ascorbate peroxidase==
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== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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The <scene name='48/486478/Cv/4'>heme-containing active site</scene> of APX contains a <scene name='48/486478/Cv/5'>His residue (H163 in soybean) which coordinates with the heme</scene> and confers stability to the Fe state in the heme. <ref>PMID:12640445</ref>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Ascorbate peroxidase
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==3D structures of ascorbate peroxidase==
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[[Ascorbate peroxidase 3D structures]]
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**[[1apx]] – APX – pea<br />
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**[[1oag]], [[2xif]], [[2xih]], [[2xi6]], [[2xj6]] – SoAPX – Soybean<br />
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**[[2cl4]], [[2ggn]], [[2ghc]], [[2ghd]], [[2ghe]], [[2ghk]], [[2ghh]], [[2vnx]], [[2vnz]], [[2vo2]], [[2y6a]], [[2y6b]], [[3zcg]], [[3zch]], [[3zcy]] – SoAPX (mutant)<br />
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**[[1iyn]] – APX – Tobacco<br />
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**[[3riv]] – LmAPX C terminal – ''Leishmania major''<br />
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**[[3riw]] - LmAPX C terminal (mutant)
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*Ascorbate peroxidase binary complex
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</StructureSection>
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**[[1oaf]] – SoAPX + ascorbate <br />
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== References ==
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**[[1v0h]] – SoAPX + salicylhydroxamic acid<br />
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<references/>
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**[[2vcf]] – SoAPX + isoniazid<br />
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**[[2vcn]], [[2vcs]] - SoAPX (mutant) + isoniazid<br />
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**[[2wd4]] - SoAPX (mutant) + biliverdin<br />
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**[[4ged]] – LmAPX + cytochrome c<br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Soybean heme-containing ascorbate peroxidase complex with ascorbate and Na+ ion (purple), 1oaf

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References

  1. ↑ Sharp KH, Mewies M, Moody PC, Raven EL. Crystal structure of the ascorbate peroxidase-ascorbate complex. Nat Struct Biol. 2003 Apr;10(4):303-7. PMID:12640445 doi:http://dx.doi.org/10.1038/nsb913

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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