Function
Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.
For details see Intramolecular Electron Transfer in Azurin.
Relevance
AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.
Structural highlights
. [1]
3D structures of azurin
Azurin 3D structures
