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3c48

From Proteopedia

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(New page: 200px {{Structure |PDB= 3c48 |SIZE=350|CAPTION= <scene name='initialview01'>3c48</scene>, resolution 2.10&Aring; |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+...)
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[[Image:3c48.jpg|left|200px]]
 
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{{Structure
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==Structure of the retaining glycosyltransferase MshA: The first step in mycothiol biosynthesis. Organism: Corynebacterium glutamicum- APO (OPEN) structure.==
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|PDB= 3c48 |SIZE=350|CAPTION= <scene name='initialview01'>3c48</scene>, resolution 2.10&Aring;
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<StructureSection load='3c48' size='340' side='right'caption='[[3c48]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+B+419'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+419'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+B+420'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+A+420'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+B+421'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+A+421'>AC6</scene>, <scene name='pdbsite=AC7:So4+Binding+Site+For+Residue+B+422'>AC7</scene> and <scene name='pdbsite=AC8:So4+Binding+Site+For+Residue+B+423'>AC8</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[3c48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C48 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= MshA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 Corynebacterium glutamicum])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00534 Glycos_transf_1], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 RfaG]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c48 OCA], [https://pdbe.org/3c48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c48 RCSB], [https://www.ebi.ac.uk/pdbsum/3c48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c48 ProSAT]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c48 OCA], [http://www.ebi.ac.uk/pdbsum/3c48 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=3c48 RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/MSHA_CORGL MSHA_CORGL] Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.<ref>PMID:18390549</ref>
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'''Structure of the retaining glycosyltransferase MshA: The first step in mycothiol biosynthesis. Organism: Corynebacterium glutamicum- APO (OPEN) structure.'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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3C48 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C48 OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/3c48_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c48 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Corynebacterium glutamicum]]
[[Category: Corynebacterium glutamicum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blanchard, J S.]]
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[[Category: Blanchard JS]]
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[[Category: Frantom, P A.]]
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[[Category: Frantom PA]]
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[[Category: Vetting, M W.]]
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[[Category: Vetting MW]]
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[[Category: beta alpha beta]]
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[[Category: retaining glycosyltransferase]]
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[[Category: substrate assisted catalysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 09:57:47 2008''
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Current revision

Structure of the retaining glycosyltransferase MshA: The first step in mycothiol biosynthesis. Organism: Corynebacterium glutamicum- APO (OPEN) structure.

PDB ID 3c48

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