Bungarotoxin
From Proteopedia
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| - | + | <StructureSection load='1hc9' size='450' side='right' scene='42/423360/Cv/5' caption='α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code [[1hc9]])'> | |
| + | [[Bungarotoxin|Bungarotoxins]]. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait.<br /> | ||
| + | * '''α-BGT''' binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in [[Alpha-bungarotoxin]].<br /> | ||
| + | * '''β-BGT''' binds to the presynaptic terminal causing release of acetylcholine.<br /> | ||
| + | * '''γ-BGT''' inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor. <br /> | ||
| + | * '''κ-BGT''' binds weakly to the nicotinic acetylcholine receptor. <br /> | ||
| + | For toxins in Proteopedia see [[Toxins]]. | ||
| - | + | <scene name='42/423360/Cv/4'>Iod coordination site</scene> in α-Bungarotoxin (PDB code [[1hc9]]).<ref>PMID:11683996</ref> Water molecule shown as red sphere. | |
== 3D Structures of Bungarotoxin == | == 3D Structures of Bungarotoxin == | ||
| - | + | [[Bungarotoxin 3D structures]] | |
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| - | + | </StructureSection> | |
| - | **[[2abx]] – α-BGT <br /> | ||
| - | **[[1kfh]], [[1ik8]], [[1ikc]], [[1idi]], [[1idl]], [[2nbt]] – α−BGT – NMR<br /> | ||
| - | **[[1bun]] - β2-BGT<br /> | ||
| - | **[[1mr6]] – γ-BGT – NMR<br /> | ||
| - | **[[1kba]] – κ-BGT<br /> | ||
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| - | * BGT+binding peptide | ||
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| - | **[[1l4w]], [[1ljz]], [[1kc4]], [[1kl8]], [[1jbd]], [[1haa]], [[1haj]], [[1idg]], [[1idh]], [[1hoy]], [[1bxp]], [[1abt]], [[1rgj]], [[2btx]] – α-BGT+AChR peptide - NMR<br /> | ||
| - | **[[1hc9]] - α-BGT+AChR peptide<br /> | ||
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| - | * BGT+ AChR subunit | ||
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| - | **[[2qc1]] – α-BGT+mAChR α subunit <br /> | ||
| - | **[[4hqp]] - α−BGT+ AChR α7 subunit<br /> | ||
| - | **[[4uy2]] - α−BGT+ AChR α9 subunit<br /> | ||
| - | }} | ||
== References == | == References == | ||
| + | <references/> | ||
[[Alpha-bungarotoxin]] | [[Alpha-bungarotoxin]] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996
