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3cjb

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(New page: 200px {{Structure |PDB= 3cjb |SIZE=350|CAPTION= <scene name='initialview01'>3cjb</scene>, resolution 3.21&Aring; |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+F...)
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[[Image:3cjb.jpg|left|200px]]
 
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{{Structure
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==Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1==
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|PDB= 3cjb |SIZE=350|CAPTION= <scene name='initialview01'>3cjb</scene>, resolution 3.21&Aring;
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<StructureSection load='3cjb' size='340' side='right'caption='[[3cjb]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+A+376'>AC1</scene>, <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+G+126'>AC2</scene> and <scene name='pdbsite=AC3:Atp+Binding+Site+For+Residue+A+377'>AC3</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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<table><tr><td colspan='2'>[[3cjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJB FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21&#8491;</td></tr>
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|GENE= GSN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00022 Actin], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00012 ACTIN], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00262 GEL]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjb OCA], [https://pdbe.org/3cjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cjb RCSB], [https://www.ebi.ac.uk/pdbsum/3cjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cjb ProSAT]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cjb OCA], [http://www.ebi.ac.uk/pdbsum/3cjb PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=3cjb RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cjb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cjb ConSurf].
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<div style="clear:both"></div>
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'''Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1'''
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==See Also==
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*[[Actin 3D structures|Actin 3D structures]]
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*[[Gelsolin 3D structures|Gelsolin 3D structures]]
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==Disease==
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__TOC__
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Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=137350 137350]]
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</StructureSection>
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==About this Structure==
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3CJB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJB OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Protein complex]]
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[[Category: Kudryashov DS]]
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[[Category: Kudryashov, D S.]]
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[[Category: Pashkov I]]
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[[Category: Pashkov, I.]]
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[[Category: Reisler E]]
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[[Category: Reisler, E.]]
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[[Category: Sawaya MR]]
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[[Category: Sawaya, M R.]]
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[[Category: Yeates TO]]
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[[Category: Yeates, T O.]]
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[[Category: acetylation]]
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[[Category: actin capping]]
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[[Category: actin-binding]]
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[[Category: alternative initiation]]
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[[Category: amyloid]]
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[[Category: atp-binding]]
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[[Category: calcium]]
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[[Category: cross-linked dimer]]
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[[Category: cytoplasm]]
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[[Category: cytoskeleton]]
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[[Category: disease mutation]]
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[[Category: methylation]]
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[[Category: muscle protein]]
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[[Category: nucleotide-binding]]
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[[Category: phosphoprotein]]
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[[Category: polymorphism]]
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[[Category: secreted]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:00:07 2008''
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Current revision

Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1

PDB ID 3cjb

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