Casein kinase

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<StructureSection load='4g16' size='450' side='right' scene='46/468136/Cv/1' caption='Human casein kinase 1 γ3 complex with inhibitor (PDB code [[4g16]])'>
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<StructureSection load='4g16' size='350' side='right' scene='46/468136/Cv/1' caption='Human casein kinase 1 γ3 complex with inhibitor (PDB code [[4g16]])'>
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__TOC__
== Function ==
== Function ==
'''Casein kinase''' (CK) is a protein kinase which functions as regulator of signal transduction.<br />
'''Casein kinase''' (CK) is a protein kinase which functions as regulator of signal transduction.<br />
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* '''CK1''' is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. <br />
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* '''CK1''' is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε.<ref>PMID:11475410</ref> <br />
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* '''CK2''' functions in cell cycle control, DNA repair and circadian rhythm regulation.
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* '''CK2''' functions in cell cycle control, DNA repair and circadian rhythm regulation.<ref>PMID:9552408</ref>
== Structural highlights ==
== Structural highlights ==
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CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. <scene name='46/468136/Cv/2'>CK1 inhibitors bind in the ATP binding pocket</scene>.<ref>PMID:22877629</ref>
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CK2 is a tetramer which contains α and α' subunits (CK2A1 and CK2A2) which are the catalytic ones and two β subunits which are the regulatory ones. <scene name='46/468136/Cv/4'>CK1 inhibitors bind in the ATP binding pocket</scene>. <ref>PMID:22877629</ref> Water molecules are shown as red spheres.
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</StructureSection>
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== 3D Structures of casein kinase ==
== 3D Structures of casein kinase ==
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[[Casein kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CK1
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**[[2c47]] – hCK1-γ2 – human<br />
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**[[2chl]] - hCK1-γ3<br />
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**[[2cmw]] – hCK1-γ1 + inhibitor<br />
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**[[2izr]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br />
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**[[3uys]] – hCK1-δ<br />
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**[[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]] – hCK1-δ + inhibitor<br />
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**[[4tw9]], [[4twc]] – hCK1-δ (mutant) + inhibitor<br />
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**[[1cki]] – rCK1-δ (mutant) – rat<br />
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**[[1ckj]] - rCK1-δ (mutant) + WO4<br />
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**[[4jjr]] - CK1-δ - mouse<br />
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**[[4hok]] - hCK1-ε <br />
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**[[4hni]] - hCK1-ε + inhibitor<br />
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**[[1csn]] – yCK1 + MgATP – fission yeast<br />
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**[[2csn]], [[1eh4]] – yCK1 catalytic domain + inhibitor
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*CK2 catalytic subunit
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**[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]] - hCK2 α subunit <br />
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**[[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant)<br />
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**[[3axw]], [[3r0t]], [[3u4u]] – hCK2 α subunit + inhibitor<br />
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**[[3ofm]] - hCK2 α’ subunit <br />
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**[[2r7i]] - rCK2 α subunit <br />
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**[[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit <br />
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*CK2 catalytic subunit binary complex
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**[[3u87]] – hCK2 α subunit + ATP analog<br />
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**[[3q9w]], [[3q9x]] – hCK2 α subunit + emodin<br />
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**[[3q9y]], [[3q9z]] – hCK2 α subunit + quinalizarin<br />
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**[[3u9c]] – hCK2 α subunit + resorufin<br />
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**[[2pvr]] - hCK2 α subunit + sulfate<br />
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**[[3rp0]] – hCK2 α subunit + α’ subunit + ATP analog
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**[[3bqc]], [[3c13]] - hCK2 α subunit + emodin
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**[[1j91]], [[4rlk]] - mCK2 α subunit + ATP competitive inhibitor - maize
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**[[1lp4]], [[1daw]], [[1day]] - mCK2 α subunit + Mg-AMPPNP
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**[[3nsz]], [[3wow]] - hCK2 α subunit + AMPPN<br />
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**[[3w8l]] - hCK2 α subunit (mutant) + inositol hexakisphosphate<br />
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**[[4dgm]] - mCK2 α subunit + apigenin<br />
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**[[4dgn]] - mCK2 α subunit + luteolin<br />
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**[[4dgo]] - mCK2 α subunit + tyrphostin<br />
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**[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor
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**[[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]], [[3axw]], [[3r0t]], [[3u4u]], [[3owj]], [[3owk]], [[3owl]], [[3wik]], [[3wil]], [[4bxa]], [[4bxb]], [[4kwp]], [[4rll]] - hCK2 α subunit + inhibitor<br />
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**[[4fbx]] - hCK2 α subunit + polypeptide inhibitor<br />
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**[[4ib5]] - hCK2 α subunit + hCK2 β polypeptide <br />
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**[[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor<br />
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**[[1f0q]], [[3pzh]] – mCK2 α subunit + emodin<br />
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**[[1zoe]], [[1zog]], [[1zoh]] – mCK2 α subunit + TBB derivative<br />
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**[[4fi1]], [[4mwh]] - yCK2 α subunit + ATP<br />
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**[[4jqe]] - yCK2 α subunit + AMPPN<br />
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**[[4jr7]], [[4lfi]] - yCK2 α subunit + GMPPNP<br />
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*CK2 regulatory subunit
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**[[1qf8]], [[3eed]] – hCK2 β subunit
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**[[2r6m]] - rCK2 β subunit
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**[[1rqf]] - CK2 β subunit + cyclin-dependent kinase peptide – ''Xenopus laevis''
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*CK2 catalytic + regulatory subunits
 
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**[[1jwh]], [[4md7]] - hCK2 α subunit + β subunit<br />
 
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**[[4dgl]], [[4md8]], [[4md9]] - hCK2 α subunit (mutant) + β subunit<br />
 
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**[[4nh1]] - hCK2 α subunit + β subunit (mutant)<br />
 
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**[[1ds5]] - mCK2 α subunit + β subunit peptide
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human casein kinase 1 γ3 complex with inhibitor (PDB code 4g16)

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References

  1. ↑ Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiol Int. 2001 May;18(3):389-98. PMID:11475410
  2. ↑ Pinna LA, Meggio F. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. Prog Cell Cycle Res. 1997;3:77-97. PMID:9552408
  3. ↑ Hua Z, Huang X, Bregman H, Chakka N, DiMauro EF, Doherty EM, Goldstein J, Gunaydin H, Huang H, Mercede S, Newcomb J, Patel VF, Turci SM, Yan J, Wilson C, Martin MW. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1gamma) inhibitors. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5392-5. doi: 10.1016/j.bmcl.2012.07.046. , Epub 2012 Jul 20. PMID:22877629 doi:10.1016/j.bmcl.2012.07.046

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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