2r0b

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[[Image:2r0b.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein==
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|PDB= 2r0b |SIZE=350|CAPTION= <scene name='initialview01'>2r0b</scene>, resolution 1.600&Aring;
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<StructureSection load='2r0b' size='340' side='right'caption='[[2r0b]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+2'>AC2</scene> and <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+A+178'>AC3</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2r0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE= STYX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00127 DSPc]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0b OCA], [https://pdbe.org/2r0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0b RCSB], [https://www.ebi.ac.uk/pdbsum/2r0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0b ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2r0b TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0b OCA], [http://www.ebi.ac.uk/pdbsum/2r0b PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2r0b RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/STYX_HUMAN STYX_HUMAN] Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).
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'''Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==Overview==
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<jmolCheckbox>
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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2R0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0B OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0b ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Bain, K T.]]
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[[Category: Bain KT]]
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[[Category: Bonanno, J B.]]
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[[Category: Bonanno JB]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Freeman, J.]]
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[[Category: Freeman J]]
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[[Category: Iizuka, M.]]
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[[Category: Iizuka M]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Romero R]]
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[[Category: Romero, R.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Smith D]]
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[[Category: Smith, D.]]
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[[Category: Wasserman S]]
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[[Category: Wasserman, S.]]
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[[Category: hydrolase]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: phosphatase]]
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[[Category: protein phosphatase]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:02:41 2008''
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Current revision

Crystal structure of human tyrosine phosphatase-like serine/threonine/tyrosine-interacting protein

PDB ID 2r0b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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