CD2
From Proteopedia
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| - | <StructureSection load='1hnf' size=' | + | <StructureSection load='1hnf' size='350' side='right' caption='Structure of glycosylated human CD2 extracellular domain complex with Na+ ion (PDB entry [[1hnf]])' scene='55/551235/Cv/1'> |
| + | == Function == | ||
'''CD2''' (or '''Cluster of Differentiation 2''') is a cell adhesion molecule found on the surface of T-cells and Natural Killer cells. CD2 has 2 immunoglobulin-like (Ig) domains in its extracellular portion.<ref>PMID:14529530</ref> | '''CD2''' (or '''Cluster of Differentiation 2''') is a cell adhesion molecule found on the surface of T-cells and Natural Killer cells. CD2 has 2 immunoglobulin-like (Ig) domains in its extracellular portion.<ref>PMID:14529530</ref> | ||
| - | *<scene name='55/551235/Cv/ | + | *<scene name='55/551235/Cv/3'>Na+ ion coordination site</scene> (PDB entry [[1hnf]]).<ref>PMID:7994575</ref> |
| - | + | </StructureSection> | |
==3D structures of CD2== | ==3D structures of CD2== | ||
Current revision
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3D structures of CD2
Updated on 10-February-2019
1cdb, 1gya – hCD2 adhesion domain – human - NMR
1hnf – hCD2 extracellular domain
1qa9 – hCD2 N terminal domain (mutant) + CD58 adhesion domain (mutant)
1hng – rCD2 extracellular domain - rat
1cdc – rCD2 N terminal domain
1a64, 1a6p, 1a7b – rCD2 adhesion domain (mutant)
1cld – CD2 (mutant) – Kluyveromyces lactis – NMR
References
- ↑ Wilkins AL, Yang W, Yang JJ. Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 2003 Oct;4(5):367-73. PMID:14529530
- ↑ Bodian DL, Jones EY, Harlos K, Stuart DI, Davis SJ. Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution. Structure. 1994 Aug 15;2(8):755-66. PMID:7994575
