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CD44
From Proteopedia
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| + | <StructureSection load='2jcq' size='350' side='right' scene='' caption='Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code [[2jcq]])'> | ||
| - | <StructureSection load='2jca' size='400' side='right' scene='52/523368/Cv/1' caption='Structure of mouse CD44 hyaluronan-binding domain complex with hyaluronic acid (PDB code [[2jca]])'> | ||
| - | </StructureSection> | ||
| - | __TOC__ | ||
== Function == | == Function == | ||
'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref> | '''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref> | ||
| - | *<scene name='52/523368/Cv/ | + | *<scene name='52/523368/Cv/4'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref> |
== Relevance == | == Relevance == | ||
CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases. | CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases. | ||
| + | </StructureSection> | ||
| + | |||
==3D structures of CD44== | ==3D structures of CD44== | ||
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[[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain – human<br /> | [[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain – human<br /> | ||
[[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br /> | [[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br /> | ||
| + | [[4pz3]] - hCD44 hyaluronan-binding domain + tetrapeptide<br /`> | ||
[[2jcp]] - mCD44 hyaluronan-binding domain – mouse<br /> | [[2jcp]] - mCD44 hyaluronan-binding domain – mouse<br /> | ||
[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br /> | [[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br /> | ||
| - | [[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], [[4np3]] - mCD44 hyaluronan-binding domain + inhibitor<br /> | + | [[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], , [[4np3]], [[5bzc]], [[5bzk]] - mCD44 hyaluronan-binding domain + inhibitor<br /> |
| + | [[5bzt]], [[5bzs]], [[5bzr]], [[5bzq]], [[5bzp]], [[5bzo]], [[5bzn]], [[5bzm]], [[5bzl]], [[5bzj]], [[5bzi]], [[5bzh]], [[5bzg]], [[5bzf]], [[5bze]] - mCD44 hyaluronan-binding domain (mutant) + inhibitor<br /> | ||
[[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br /> | [[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br /> | ||
| + | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of CD44
Updated on 02-June-2021
1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk - mCD44 hyaluronan-binding domain + inhibitor
5bzt, 5bzs, 5bzr, 5bzq, 5bzp, 5bzo, 5bzn, 5bzm, 5bzl, 5bzj, 5bzi, 5bzh, 5bzg, 5bzf, 5bze - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide
References
- ↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532
- ↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201
