Beta-ketoacyl-ACP reductase

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<StructureSection load='1q7b' size='350' side='right' caption='Structure of beta-ketoacyl carrier protein reductase complex with NADP and Ca+2 ion (green) (PDB code [[1q7b]]).' scene='59/593279/Cv/1'>
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#REDIRECT [[Beta-hydroxyacyl-acyl_carrier_protein_dehydratase]]
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__TOC__
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== Function ==
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'''Beta-ketoacyl carrier protein reductase''' (BKACPR) catalyzes the reaction of conversion of 3-hydroxyacyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein] while using NADPH as a reducing agent. BKACPR is part of the type II fatty acid biosynthesis pathway. '''Pimelyl carrier protein reductase''' (ACPR) is involved in the assembly pathway of the pimeloyl moiety of biotin.
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== Relevance ==
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BKACPR from ''Plasmodium falciparium'' inhibitors are tested as antimalarial drugs. Other BKACPR inhibitors are tested for combating toxoplasmosis and sleeping sickness.
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== Structural highlights ==
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The <scene name='59/593279/Cv/2'>active site</scene> interacting with co-factor NADPH contains the active site catalytic triad <scene name='59/593279/Cv/3'>S138, Y151, K155</scene> (in E. coli, PDB code [[1q7b]]).<ref>PMID:15016358</ref>
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</StructureSection>
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==3D structures of beta-ketoacyl carrier protein reductase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Beta-ketoacyl carrier protein reductase
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**[[1i01]] – EcBKACPR – ''Escherichia coli''<br />
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**[[1uzl]], [[3lls]] – MtBKACPR – ''Mycobacterium tuberculosis''<br />
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**[[1uzm]], [[2ntn]] – MtBKACPR (mutant) <br />
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**[[2p68]], [[2pnf]] – BKACPR – ''Aquifex aeolicus''<br />
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**[[3f9i]] – BKACPR – ''Rickettsia prowazekii''<br />
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**[[3osu]] – BKACPR – ''Staphylococcus aureus''<br />
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**[[3rro]] – VcBKACPR – ''Vibrio cholerae''<br />
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**[[3u09]], [[4wjz]] – VcBKACPR (mutant) <br />
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**[[4ijk]] – HpBKACPR – ''Helicobacter pylori'' <br />
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**[[4afn]] – PaBKACPR – ''Pseudomonas aeruginosa''<br />
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**[[4fd3]] – yBKACPR - yeast<br />
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*Beta-ketoacyl carrier protein reductase complex
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**[[1q7b]] – EcBKACPR + NADP<br />
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**[[1q7c]] – EcBKACPR (mutant) + NADP<br />
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**[[1uzn]] – MtBKACPR (mutant) + NADP<br />
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**[[2b4q]], [[4ag3]] – PaBKACPR + NADP <br />
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**[[3rsh]], [[4i08]] – VcBKACPR + NADP <br />
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**[[4iin]] – HpBKACPR + NAD <br />
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**[[4fda]], [[4hbg]] – yBKACPR + NADP <br />
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**[[4bnt]], [[4bnu]], [[4bnv]], [[4bnw]], [[4bnx]], [[4bny]], [[4bnz]], [[4bo0]], [[4bo1]], [[4bo2]], [[4bo3]], [[4bo4]], [[4bo5]], [[4bo6]], [[4bo7]], [[4bo8]], [[4bo9]] – PaBKACPR + inhibitor<br />
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*Specialized beta-ketoacyl carrier protein reductase
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**[[3lmo]] – RpACPR – ''Rhodopseudomonas palustris''<br />
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**[[2kw2]], [[2ll8]], [[2lpk]] – RpACPR – NMR<br />
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*Pimelyl carrier protein reductase
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**[[4etw]] – ACPR – ''Shigella flexneri''<br />
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**[[4nmw]] – ACPR – ''Samonella enterica''<br />
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*Enoyl carrier protein reductase see [[Enoyl-Acyl-Carrier Protein Reductase]]
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]
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Current revision

  1. REDIRECT Beta-hydroxyacyl-acyl_carrier_protein_dehydratase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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