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4co7

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==Crystal structure of human GATE-16==
==Crystal structure of human GATE-16==
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<StructureSection load='4co7' size='340' side='right' caption='[[4co7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4co7' size='340' side='right'caption='[[4co7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4co7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CO7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4co7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CO7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4co7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4co7 OCA], [http://pdbe.org/4co7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4co7 RCSB], [http://www.ebi.ac.uk/pdbsum/4co7 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4co7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4co7 OCA], [https://pdbe.org/4co7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4co7 RCSB], [https://www.ebi.ac.uk/pdbsum/4co7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4co7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GBRL2_HUMAN GBRL2_HUMAN]] Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.<ref>PMID:20418806</ref> <ref>PMID:23209295</ref>
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[https://www.uniprot.org/uniprot/GBRL2_HUMAN GBRL2_HUMAN] Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.<ref>PMID:20418806</ref> <ref>PMID:23209295</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4co7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4co7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ma, P]]
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[[Category: Homo sapiens]]
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[[Category: Weiergraeber, O H]]
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[[Category: Large Structures]]
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[[Category: Willbold, D]]
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[[Category: Ma P]]
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[[Category: Autophagy]]
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[[Category: Weiergraeber OH]]
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[[Category: Beta-grasp fold]]
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[[Category: Willbold D]]
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[[Category: Protein transport]]
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[[Category: Ubiquitin superfamily]]
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Current revision

Crystal structure of human GATE-16

PDB ID 4co7

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