5bpg

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==Crystal structure of the water-soluble FraC purified starting from the trans-membrane pore==
==Crystal structure of the water-soluble FraC purified starting from the trans-membrane pore==
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<StructureSection load='5bpg' size='340' side='right' caption='[[5bpg]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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<StructureSection load='5bpg' size='340' side='right'caption='[[5bpg]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5bpg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5bpg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpg OCA], [http://pdbe.org/5bpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpg RCSB], [http://www.ebi.ac.uk/pdbsum/5bpg PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpg OCA], [https://pdbe.org/5bpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpg RCSB], [https://www.ebi.ac.uk/pdbsum/5bpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
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[https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5bpg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5bpg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caaveiro, J M.M]]
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[[Category: Actinia fragacea]]
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[[Category: Tanaka, K]]
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[[Category: Large Structures]]
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[[Category: Tsumoto, K]]
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[[Category: Caaveiro JMM]]
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[[Category: Actinoporin]]
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[[Category: Tanaka K]]
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[[Category: Detergent]]
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[[Category: Tsumoto K]]
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[[Category: Lipid-protein interaction]]
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[[Category: Membrane lipid]]
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[[Category: Pore-forming toxin]]
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[[Category: Protein folding]]
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[[Category: Protein-detergent interaction]]
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[[Category: Toxin]]
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Current revision

Crystal structure of the water-soluble FraC purified starting from the trans-membrane pore

PDB ID 5bpg

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