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4c1f

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==Crystal structure of the metallo-beta-lactamase IMP-1 with L-captopril==
==Crystal structure of the metallo-beta-lactamase IMP-1 with L-captopril==
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<StructureSection load='4c1f' size='340' side='right' caption='[[4c1f]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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<StructureSection load='4c1f' size='340' side='right'caption='[[4c1f]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c1f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C1F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bz3|4bz3]], [[4c09|4c09]], [[4c1c|4c1c]], [[4c1d|4c1d]], [[4c1e|4c1e]], [[4c1g|4c1g]], [[4c1h|4c1h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X8Z:L-CAPTOPRIL'>X8Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1f OCA], [https://pdbe.org/4c1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1f RCSB], [https://www.ebi.ac.uk/pdbsum/4c1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1f OCA], [http://pdbe.org/4c1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c1f RCSB], [http://www.ebi.ac.uk/pdbsum/4c1f PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
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[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Brem, J]]
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[[Category: Serratia marcescens]]
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[[Category: McDonough, M A]]
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[[Category: Brem J]]
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[[Category: Schofield, C J]]
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[[Category: McDonough MA]]
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[[Category: Zollman, D]]
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[[Category: Schofield CJ]]
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[[Category: VanBerkel, S S]]
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[[Category: Zollman D]]
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[[Category: Antibiotic resistance]]
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[[Category: Van Berkel SS]]
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[[Category: Hydrolase]]
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[[Category: Mbl]]
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[[Category: Metallo-beta-lactamase]]
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Current revision

Crystal structure of the metallo-beta-lactamase IMP-1 with L-captopril

PDB ID 4c1f

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