This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4zyg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:01, 10 January 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase==
==Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase==
-
<StructureSection load='4zyg' size='340' side='right' caption='[[4zyg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+
<StructureSection load='4zyg' size='340' side='right'caption='[[4zyg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zyg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZYG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZYG FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyg OCA], [http://pdbe.org/4zyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zyg RCSB], [http://www.ebi.ac.uk/pdbsum/4zyg PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zyg OCA], [https://pdbe.org/4zyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zyg RCSB], [https://www.ebi.ac.uk/pdbsum/4zyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zyg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/OGT_SULSO OGT_SULSO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
+
[https://www.uniprot.org/uniprot/OGT_SACS2 OGT_SACS2] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.[HAMAP-Rule:MF_00772]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 4zyg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zyg" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Miggiano, R]]
+
[[Category: Large Structures]]
-
[[Category: Rizzi, M]]
+
[[Category: Saccharolobus solfataricus]]
-
[[Category: Rossi, F]]
+
[[Category: Miggiano R]]
-
[[Category: Alkylated dna-protein alkyltransferase]]
+
[[Category: Rizzi M]]
-
[[Category: Dna repair]]
+
[[Category: Rossi F]]
-
[[Category: Extremophile]]
+
-
[[Category: Methylated protein]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase

PDB ID 4zyg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zyg"
Personal tools