2n8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the rNedd4 WW1 Domain by NMR== | |
| + | <StructureSection load='2n8s' size='340' side='right'caption='[[2n8s]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N8S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8s OCA], [https://pdbe.org/2n8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n8s RCSB], [https://www.ebi.ac.uk/pdbsum/2n8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n8s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NEDD4_RAT NEDD4_RAT] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Is involved in ubiquitination of ERBB4 intracellular domain E4ICD. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).<ref>PMID:20159449</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Kieken | + | </StructureSection> |
| - | [[Category: Sorgen | + | [[Category: Large Structures]] |
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Kieken F]] | ||
| + | [[Category: Sorgen PL]] | ||
| + | [[Category: Spagnol G]] | ||
Current revision
Solution Structure of the rNedd4 WW1 Domain by NMR
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